A variety of targeted nanoparticles were developed for the diagnosis and therapy of
orthotopic and metastatic bone tumors during the past decade. This critical review will focus …

Bones provide essential functions and are sites of unique biochemistry and specialized
cells, but can also be sites of disease. The treatment of bone disorders and neoplasia has …

The high concentration of mineral present in bone and pathological calcifications is unique
compared with all other tissues and thus provides opportunity for targeted delivery of …

Since their discovery over 100years ago, bisphosphonates have been used industrially as
corrosion inhibitors and complexing agents. With the discovery of their pharmacological …

Inflammation is a defensive mechanism for pathogen clearance and maintaining tissue
homeostasis. In the skeletal system, inflammation is closely associated with many bone …

A review of recent advances in instrumental methods and techniques for structural and
physicochemical characterization of biomaterials and bone tissue is presented in this paper …

Peptides have great potential as therapeutic agents, however, their clinic applications are
severely hampered by their instability and short circulation half-life. Zero-order release …

Introduction: Bisphosphonates (BPs) were introduced 45 years ago as anti-osteoporotic
drugs and during the last decade have been utilized as bone-targeting groups in systemic …

Bone is a connective tissue that support the entire body and protect the internal organs.
However, there are great challenges on curing intractable skeletal diseases such as …

Bone metastases are common in malignant tumors and the effect of conventional treatment
is limited. How to effectively inhibit tumor bone metastasis and deliver the drug to the bone …