From pre-diabetes to diabetes: diagnosis, treatments and translational research

RMM Khan, ZJY Chua, JC Tan, Y Yang, Z Liao, Y Zhao - Medicina, 2019 - mdpi.com
Diabetes, a silent killer, is one of the most widely prevalent conditions of the present time.
According to the 2017 International Diabetes Federation (IDF) statistics, the global …

Pathophysiology of human visceral obesity: an update

A Tchernof, JP Després - Physiological reviews, 2013 - journals.physiology.org
Excess intra-abdominal adipose tissue accumulation, often termed visceral obesity, is part of
a phenotype including dysfunctional subcutaneous adipose tissue expansion and ectopic …

Adipocyte differentiation from the inside out

ED Rosen, OA MacDougald - Nature reviews Molecular cell biology, 2006 - nature.com
Improved knowledge of all aspects of adipose biology will be required to counter the
burgeoning epidemic of obesity. Interest in adipogenesis has increased markedly over the …

Transcriptional control of adipocyte formation

SR Farmer - Cell metabolism, 2006 - cell.com
A detailed understanding of the processes governing adipose tissue formation will be
instrumental in combating the obesity epidemic. Much progress has been made in the last …

Adipose organ development and remodeling

S Cinti - Comprehensive Physiology, 2018 - iris.univpm.it
During the last decades, research on adipose tissues has spread in parallel with the
extension of obesity. Several observations converged on the idea that adipose tissues are …

The many faces of PPARγ

M Lehrke, MA Lazar - Cell, 2005 - cell.com
In an era marked by the increasing prevalence of obesity, diabetes, and cardiovascular
disease, the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) has …

New developments in adipogenesis

MI Lefterova, MA Lazar - Trends in Endocrinology & Metabolism, 2009 - cell.com
The obesity epidemic has focused attention on adipose tissue and the development of fat
cells (ie adipocytes), which is known as adipogenesis. Peroxisome proliferator-activated …

The human obesity gene map: the 2005 update

T Rankinen, A Zuberi, YC Chagnon, SJ Weisnagel… - …, 2006 - Wiley Online Library
This paper presents the 12th update of the human obesity gene map, which incorporates
published results up to the end of October 2005. Evidence from single‐gene mutation …

The unfolded protein response transducer IRE1α prevents ER stress‐induced hepatic steatosis

K Zhang, S Wang, J Malhotra, JR Hassler… - The EMBO …, 2011 - embopress.org
The endoplasmic reticulum (ER) is the cellular organelle responsible for protein folding and
assembly, lipid and sterol biosynthesis, and calcium storage. The unfolded protein response …

Loss of perivascular adipose tissue on peroxisome proliferator–activated receptor-γ deletion in smooth muscle cells impairs intravascular thermoregulation and …

L Chang, L Villacorta, R Li, M Hamblin, W Xu, C Dou… - Circulation, 2012 - Am Heart Assoc
Background—Perivascular adipose tissue (PVAT) surrounds most vessels and shares
common features with brown adipose tissue (BAT). Although adaptive thermogenesis in BAT …