Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …

Transforming growth factor-β1 (TGF-β1) is considered as a crucial mediator in tissue fibrosis
and causes tissue scarring largely by activating its downstream small mother against …

Fibrosis occurs when there is an imbalance in extracellular matrix (ECM) deposition and
degradation. Excessive ECM deposition results in scarring and thickening of the affected …

Chronic kidney disease (CKD) has emerged as a major cause of morbidity and mortality
worldwide. Interstitial fibrosis, glomerulosclerosis and inflammation play the central role in …

The accurate definition and staging of chronic kidney disease (CKD) is one of the major
achievements of modern nephrology. Intensive research is now being undertaken to unravel …

Inflammation and fibrosis are two pathological features of chronic kidney disease (CKD).
Transforming growth factor-β (TGF-β) has been long considered as a key mediator of renal …

Transforming growth factor-β (TGF-β) is a central player in fibrotic disease. Clinical trials with
global inhibitors of TGF-β have been disappointing, suggesting that a more targeted …

Renal fibrosis is characterized by excessive deposition of extracellular matrix (ECM),
leading to destruction of normal kidney architecture and loss of renal function. The activation …

Human fibrotic diseases constitute a major health problem worldwide owing to the large
number of affected individuals, the incomplete knowledge of the fibrotic process …

Circulating proteins associated with transforming growth factor–β (TGF-β) signaling are
implicated in the development of diabetic kidney disease (DKD). It remains to be …