Age-associated neurological diseases represent a profound challenge in biomedical
research as we are still struggling to understand the interface between the aging process …

The scarcity of live human brain cells for experimental access has for a long time limited our
ability to study complex human neurological disorders and elucidate basic neuroscientific …

Abstract Treatment with androgen receptor pathway inhibitors (ARPIs) in prostate cancer
leads to the emergence of resistant tumors characterized by lineage plasticity and …

Tractable and accurate disease models are essential for understanding disease
pathogenesis and for developing new therapeutics. As stem cells are capable of self …

Direct cell reprogramming enables direct conversion of fibroblasts into functional neurons
and oligodendrocytes using a minimal set of cell-lineage-specific transcription factors. This …

Complex brain disorders are highly heritable and arise from a complex polygenic risk
architecture. Many disease-associated loci are found in non-coding regions that house …

A major hallmark of Parkinson's disease is loss of dopaminergic neurons in the substantia
nigra pars compacta (SNpc). The pathophysiological mechanisms causing this relatively …

Dopamine replacement therapy in Parkinson's disease is associated with several unwanted
effects, of which dyskinesia is the most disabling. The development of new therapeutic …

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have been used as
promising tools for regenerative medicine, disease modeling, and drug screening …

Recent advances in the field of cellular reprogramming have opened a route to studying the
fundamental mechanisms underlying common neurological disorders. High‐density …