Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements
in recent years. It has been observed that cartilage degeneration is preceded by …

This year in review on osteoarthritis biology summarizes a series of research articles
published between the 2020 and 2021 Osteoarthritis Research Society International …

Articular cartilage (AC) has limited capacity for repair. The first attempt to repair cartilage
using tissue engineering was reported in 1977. Since then, cell-based interventions have …

Abstract Growth differentiation factor 5 (GDF‐5) is essential for cartilage development and
homeostasis. The expression and function of GDF‐5 are highly associated with the …

Abstract Purpose of Review Here, we discuss the origin of chondrocytes, their destiny, and
their plasticity in relationship to bone growth, articulation, and formation of the trabeculae …

Articular cartilage has low regenerative capacity despite permanent stress. Irreversible
cartilage lesions characterize osteoarthritis (OA); this is not followed by tissue repair. Lin28a …

Objective We aimed to understand the role of the transcriptional co-factor Yes-associated
protein (Yap) in the molecular pathway underpinning the pathogenic transformation of …

Osteoarthritis (OA) is a degenerative joint disease affecting millions of people worldwide. In
OA, chondrocytes, synovial cells and other joint cells become activated when exposed to an …

ABSTRACT The Cre/Lox system is a powerful tool in the biologist's toolbox, allowing loss‐of‐
function and gain‐of‐function studies, as well as lineage tracing, through gene …

Osteogenesis imperfecta (OI) is a disorder of low bone mass and increased fracture risk due
to a range of genetic variants that prominently include mutations in genes encoding type I …