Brain mitochondrial dysfunction is involved in the development of neurological and
neurodegenerative diseases. Mitochondria specifically located at synapses play a key role …

To form and maintain extremely intricate and functional neural circuitry, mammalian neurons
are typically endowed with highly arborized dendrites and a long axon. The synapses that …

Neurons have complex and often extensively elongated processes. This unique cell
morphology raises the problem of how remote neuronal territories are replenished with …

Cystatin B (CSTB) is a ubiquitous protein belonging to a superfamily of protease inhibitors.
CSTB may play a critical role in brain physiology because its mutations cause progressive …

Some forms of learning and memory and their electrophysiologic correlate, long-term
potentiation (LTP), require dendritic translation. We demonstrate that Pin1 (protein …

While protein synthesis in neurons is largely attributed to cell body and dendrites, the
capability of synaptic regions to synthesize new proteins independently of the cell body has …

Neurodegenerative diseases (NDDs) are characterized by cognitive impairment and
behavioural abnormalities. The incidence of NDDs in recent years has increased globally …

Synapses are the cellular substrates of higher-order brain functions, and their dysfunction is
an early and primary pathogenic mechanism across several neurological disorders. In …

Cystatin B (CSTB) is a small protease inhibitor protein being involved in cell proliferation
and neuronal differentiation. Loss-of-function mutations in CSTB gene cause progressive …

The cytoskeleton and its associated proteins present at the plasma membrane not only
determine the cell shape but also modulate important aspects of cell physiology such as …