MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma

B Otoukesh, M Abbasi, HL Gorgani, H Farahini… - Cancer cell …, 2020 - Springer
MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of
osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 …

MicroRNA function and dysregulation in bone tumors: the evidence to date

M Nugent - Cancer management and research, 2014 - Taylor & Francis
Micro ribonucleic acids (miRNAs) are small non-coding RNA segments that have a role in
the regulation of normal cellular development and proliferation including normal …

[HTML][HTML] miRNA expression profile in human osteosarcoma: role of miR-1 and miR-133b in proliferation and cell cycle control

C Novello, L Pazzaglia… - International …, 2013 - spandidos-publications.com
Abstract miRNA profile deregulation affecting downstream signaling pathways activates
endpoints that represent potential biomarkers for prognosis and treatment of tumor patients …

MicroRNA-93 downregulation ameliorates cerebral ischemic injury through the Nrf2/HO-1 defense pathway

P Wang, X Liang, Y Lu, X Zhao, J Liang - Neurochemical research, 2016 - Springer
The present study was designed to evaluate the potential role of miR-93 in cerebral
ischemic/reperfusion (I/R) injury in mice. The stroke model was produced in C57BL/6 J mice …

[HTML][HTML] Overexpression of miR-196b and HOXA10 characterize a poor-prognosis gastric cancer subtype

JY Lim, SO Yoon, SY Seol, SW Hong… - World journal of …, 2013 - ncbi.nlm.nih.gov
AIM: To identify molecular biologic differences between two gastric adenocarcinoma
subgroups presenting different prognoses through the analysis of microRNA and protein …

[HTML][HTML] CTGF increases matrix metalloproteinases expression and subsequently promotes tumor metastasis in human osteosarcoma through down-regulating miR …

HC Tsai, HL Su, CY Huang, YC Fong, CJ Hsu… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Osteosarcoma, the most common primary malignant bone tumor, shows potent capacity for
local invasion and distant metastasis. Connective tissue growth factor (CTGF/CCN2), a …

Identification of dormancy-associated microRNAs for the design of osteosarcoma-targeted dendritic polyglycerol nanopolyplexes

G Tiram, E Segal, A Krivitsky, R Shreberk-Hassidim… - ACS …, 2016 - ACS Publications
The presence of dormant, microscopic cancerous lesions poses a major obstacle for the
treatment of metastatic and recurrent cancers. While it is well-established that microRNAs …

[HTML][HTML] miR-16 inhibits cell proliferation by targeting IGF1R and the Raf1–MEK1/2–ERK1/2 pathway in osteosarcoma

L Chen, Q Wang, G Wang, H Wang, Y Huang, X Liu… - FEBS letters, 2013 - Elsevier
Several miRNAs have been implicated in the development and progression of
osteosarcoma (OS). In this study, we found that miR-16 is downregulated in OS cell lines …

[HTML][HTML] MicroRNA-34a inhibits human osteosarcoma proliferation by downregulating ether a go-go 1 expression

X Wu, D Zhong, Q Gao, W Zhai, Z Ding… - International journal of …, 2013 - ncbi.nlm.nih.gov
Aberrant expression of MicroRNAs (miRNAs) has been implicated in several types of
cancer. As a direct target gene of p53, miR-34a has been suggested to mediate the tumor …

A novel molecular classification method for osteosarcoma based on tumor cell differentiation trajectories

H Zhang, T Wang, H Gong, R Jiang, W Zhou, H Sun… - Bone Research, 2023 - nature.com
Subclassification of tumors based on molecular features may facilitate therapeutic choice
and increase the response rate of cancer patients. However, the highly complex cell origin …