Intervertebral disc (IVD) degeneration is one of the major causes of low back pain, a
problem with a heavy economic burden, which has been increasing in prevalence as …

Lumbar disc herniation (LDH) is highly associated with inflammation in the context of low
back pain. Currently, inflammation is associated with adverse symptoms related to the …

Chronic low back pain (CLBP), lasting> 3 months, is the end result of multiple pathogenic
factors. Unfortunately, little is known about CLBP pathogenesis, which limits its …

Intervertebral disc (IVD) herniation and degeneration contributes significantly to low back
pain (LBP), of which the molecular pathogenesis is not fully understood. Disc herniation may …

Authored by experts of international renown, the new edition of The Biomechanics of Back
Pain forms a bridge between the latest research and the effective clinical management of …

Objective These studies investigated cytokine and chemokine receptor profiles in nucleus
pulposus (NP) cells, and the effects of receptor stimulation on mRNA levels of extracellular …

Intervertebral disc degeneration (IDD) is a primary contributor to low back pain. Immune
cells play an extremely important role in modulating the progression of IDD by interacting …

Study Design. Mechanical and biochemical analyses of cadaveric and surgically removed
discs. Objective. To test the hypothesis that fissures in the annulus of degenerated human …

Up until fairly recently, it was thought that sciatic pain in the lumbar herniated disc was
caused by compression on the nerve root. However, the lumbar herniated disc shows mixed …

Introduction The aims of these studies were to identify the cytokine and chemokine
expression profile of nucleus pulposus (NP) cells and to determine the relationships …