(1) Background: Scleroderma (Sc) is a rare connective tissue disease classified as an
autoimmune disorder. The pathogenesis of this disease is not fully understood.(2) Methods …

Calcinosis cutis is the deposition of insoluble calcium in the skin and subcutaneous tissues.
It represents a major clinical problem in patients with SSc affecting at least one quarter of …

Background We have limited data on the treatment of calcinosis cutis associated with
systemic sclerosis and dermatomyositis. Objective To assess the efficacy and tolerance of …

Calcinosis (hydroxyapatite and calcium phosphate crystal deposition) within the
extracellular matrix of the dermis and subcutaneous tissue is a frequent manifestation of …

Calcinosis represents a severe complication of several autoimmune disorders. Soft-tissue
calcifications have been classified into five major types: dystrophic, metastatic, idiopathic …

Background. Systemic sclerosis (SSc) is a chronic multisystem autoimmune condition
defined by a complex pathobiology, comprising excessive fibrosis of skin and internal …

Objective Calcinosis is a debilitating complication of systemic sclerosis (SSc) with no
effective treatments. We sought to identify clinical correlations and to characterize …

Skin ulcers in scleroderma (SSc) patients are considered a major challenge, both in clinical
assessment and treatment decisions. The objective of our study is to assess …

Introduction Calcinosis cutis is a debilitating complication of systemic sclerosis (SSc). We
previously developed a radiographic scoring system to assess severity of calcinosis …

Calcinosis is dystrophic calcification of the soft tissue which can lead to painful and
debilitating disease. It is commonly seen in patients with systemic sclerosis (SSc). Imaging …