Burns and their treatment are a significant medical problem. The loss of the physical barrier
function of the skin opens the door to microbial invasion and can lead to infection. The repair …

Major burns provoke a profound stress response, which is unrivalled in terms of its
magnitude and duration. Evidence suggests that the pathophysiological stress response to …

Since the presence of brown adipose tissue (BAT) was confirmed in adult humans, BAT has
become a therapeutic target for obesity and insulin resistance. We examined whether …

Burn is an under-appreciated trauma that is associated with unacceptably high morbidity
and mortality. Although the survival rate after devastating burn injuries has continued to …

Background Main contributors to adverse outcomes in severely burned pediatric patients are
profound and complex metabolic changes in response to the initial injury. It is currently …

Severe burn causes significant metabolic derangements that make nutritional support
uniquely important and challenging for burned patients. Burn injury causes a persistent and …

Severe burn causes metabolic disturbances that can last for a year after injury; persistent
and profound catabolism hampers rehabilitative efforts and delays the meaningful return of …

Severe thermal injury, defined as burns encompassing over 40% of a patient's total body
surface area (TBSA), is followed by a pronounced hypermetabolic response that persists for …

In the sanctity of pure drug discovery, objective reasoning can become clouded when
pursuing ideas that appear unorthodox, but are spot on physiologically. To put this into …

Critical illnesses, including sepsis, cancer cachexia, and burn injury, invoke a milieu of
systemic metabolic and inflammatory derangements that ultimately results in increased …