Natural killer cells in antitumour adoptive cell immunotherapy

TJ Laskowski, A Biederstädt, K Rezvani - Nature Reviews Cancer, 2022 - nature.com
Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with
intrinsic abilities to identify and eliminate virally infected cells and tumour cells. Possessing …

CAR-NK cells for cancer immunotherapy: from bench to bedside

L Zhang, Y Meng, X Feng, Z Han - Biomarker Research, 2022 - Springer
Natural killer (NK) cells are unique innate immune cells and manifest rapid and potent
cytotoxicity for cancer immunotherapy and pathogen removal without the requirement of …

Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia

H Dong, JD Ham, G Hu, G Xie… - Proceedings of the …, 2022 - National Acad Sciences
Acute myeloid leukemia (AML) remains a therapeutic challenge, and a paucity of tumor-
specific targets has significantly hampered the development of effective immune-based …

Expansion, persistence, and efficacy of donor memory-like NK cells infused for posttransplant relapse

RM Shapiro, GC Birch, G Hu… - The Journal of …, 2022 - Am Soc Clin Investig
Background Responses to conventional donor lymphocyte infusion for postallogeneic
hematopoietic cell transplantation (HCT) relapse are typically poor. Natural killer (NK) cell …

Allogeneic natural killer cell therapy

MM Berrien-Elliott, MT Jacobs, TA Fehniger - Blood, 2023 - ashpublications.org
Interest in adoptive cell therapy for treating cancer is exploding owing to early clinical
successes of autologous chimeric antigen receptor (CAR) T lymphocyte therapy. However …

Hematopoietic cell transplantation donor-derived memory-like NK cells functionally persist after transfer into patients with leukemia

MM Berrien-Elliott, JA Foltz… - Science translational …, 2022 - science.org
Natural killer (NK) cells are innate lymphoid cells that eliminate cancer cells, produce
cytokines, and are being investigated as a nascent cellular immunotherapy. Impaired NK …

Human NK cells, their receptors and function

L Quatrini, M Della Chiesa, S Sivori… - European journal of …, 2021 - Wiley Online Library
NK cells are cytotoxic components of innate lymphoid cells (ILC) that provide a first line of
defense against viral infections and contribute to control tumor growth and metastasis. Their …

Donor memory-like NK cells persist and induce remissions in pediatric patients with relapsed AML after transplant

JJ Bednarski, C Zimmerman… - Blood, The Journal …, 2022 - ashpublications.org
Pediatric and young adult (YA) patients with acute myeloid leukemia (AML) who relapse
after allogeneic hematopoietic cell transplantation (HCT) have an extremely poor prognosis …

Systemic IL-15 promotes allogeneic cell rejection in patients treated with natural killer cell adoptive therapy

MM Berrien-Elliott, M Becker-Hapak… - Blood, The Journal …, 2022 - ashpublications.org
Natural killer (NK) cells are a promising alternative to T cells for cancer immunotherapy.
Adoptive therapies with allogeneic, cytokine-activated NK cells are being investigated in …

Overcoming tumor resistance mechanisms in CAR-NK cell therapy

A Valeri, A García-Ortiz, E Castellano… - Frontiers in …, 2022 - frontiersin.org
Despite the impressive results of autologous CAR-T cell therapy in refractory B
lymphoproliferative diseases, CAR-NK immunotherapy emerges as a safer, faster, and cost …