Reappraising the role of inflammation in heart failure
The observation that heart failure with reduced ejection fraction is associated with elevated
circulating levels of pro-inflammatory cytokines opened a new area of research that has …
circulating levels of pro-inflammatory cytokines opened a new area of research that has …
Inflammatory cytokines and chemokines as therapeutic targets in heart failure
A Hanna, NG Frangogiannis - Cardiovascular Drugs and Therapy, 2020 - Springer
Heart failure exhibits remarkable pathophysiologic heterogeneity. A large body of evidence
suggests that regardless of the underlying etiology, heart failure is associated with induction …
suggests that regardless of the underlying etiology, heart failure is associated with induction …
Anti-inflammatory therapy with canakinumab for the prevention of hospitalization for heart failure
Background: Subclinical inflammation is associated with an increased risk of heart failure
and with adverse prognosis in patients with established heart failure. Yet, treatments …
and with adverse prognosis in patients with established heart failure. Yet, treatments …
Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-α, in patients with moderate-to-severe …
Background–Preclinical and preliminary clinical data have suggested that tumor necrosis
factor-α (TNFα) may play a role in the evolution and progression of heart failure and that …
factor-α (TNFα) may play a role in the evolution and progression of heart failure and that …
[HTML][HTML] Current and future therapeutic perspective in chronic heart failure
A Mascolo, G Di Mauro, D Cappetta… - Pharmacological …, 2022 - Elsevier
The incidence of heart failure is primarily flat or declining for a presumably reflecting better
management of cardiovascular diseases, but that of heart failure with preserved ejection …
management of cardiovascular diseases, but that of heart failure with preserved ejection …
Inflammatory mediators and the failing heart: past, present, and the foreseeable future
DL Mann - Circulation research, 2002 - Am Heart Assoc
Recent studies have identified the importance of proinflammatory mediators in the
development and progression of heart failure. The growing appreciation of the …
development and progression of heart failure. The growing appreciation of the …
Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum.
A Kumar, V Thota, L Dee, J Olson, E Uretz… - The Journal of …, 1996 - rupress.org
Previous studies have demonstrated the presence of myocardial depression in clinical and
experimental septic shock. This depression is associated with the presence of a circulating …
experimental septic shock. This depression is associated with the presence of a circulating …
Mechanisms of sepsis-induced cardiac dysfunction
Objectives: To review mechanisms underlying sepsis-induced cardiac dysfunction in
general and intrinsic myocardial depression in particular. Data Source: MEDLINE database …
general and intrinsic myocardial depression in particular. Data Source: MEDLINE database …
Tumor necrosis factor-α and tumor necrosis factor receptors in the failing human heart
Background Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine that produces
negative inotropic effects in the heart. Recently, elevated levels of TNF-α have been …
negative inotropic effects in the heart. Recently, elevated levels of TNF-α have been …
Pathophysiologically relevant concentrations of tumor necrosis factor-α promote progressive left ventricular dysfunction and remodeling in rats
B Bozkurt, SB Kribbs, FJ Clubb Jr, LH Michael… - Circulation, 1998 - Am Heart Assoc
Background—Although patients with heart failure express elevated circulating levels of
tumor necrosis factor-α (TNF-α) in their peripheral circulation, the structural and functional …
tumor necrosis factor-α (TNF-α) in their peripheral circulation, the structural and functional …