Sensory processing dysfunction in the personal experience and neuronal machinery of schizophrenia

DC Javitt, R Freedman - American Journal of Psychiatry, 2015 - Am Psychiatric Assoc
Sensory processing deficits, first investigated by Kraepelin and Bleuler as possible
pathophysiological mechanisms in schizophrenia, are now being recharacterized in the …

Cognitive impairment associated with schizophrenia: from pathophysiology to treatment

DC Javitt - Annual Review of Pharmacology and Toxicology, 2023 - annualreviews.org
Cognitive impairment is a core feature of schizophrenia and a major contributor to poor
functional outcomes. Methods for assessment of cognitive dysfunction in schizophrenia are …

N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: the final common pathway on the road to schizophrenia?

JT Kantrowitz, DC Javitt - Brain research bulletin, 2010 - Elsevier
Schizophrenia is a severe mental disorder associated with a characteristic constellation of
symptoms and neurocognitive deficits. At present, etiological mechanisms remain relatively …

When doors of perception close: bottom-up models of disrupted cognition in schizophrenia

DC Javitt - Annual review of clinical psychology, 2009 - annualreviews.org
Schizophrenia is a major mental disorder that affects approximately 1% of the population
worldwide. Cognitive deficits are a key feature of schizophrenia and a primary cause of long …

Visual perception and its impairment in schizophrenia

PD Butler, SM Silverstein, SC Dakin - Biological psychiatry, 2008 - Elsevier
Much work in the cognitive neuroscience of schizophrenia has focused on attention,
memory, and executive functioning. To date, less work has focused on perceptual …

Top-down predictions in the cognitive brain

K Kveraga, AS Ghuman, M Bar - Brain and cognition, 2007 - Elsevier
The human brain is not a passive organ simply waiting to be activated by external stimuli.
Instead, we propose that the brain continuously employs memory of past experiences to …

Multimodal neuroimaging in schizophrenia: description and dissemination

CJ Aine, HJ Bockholt, JR Bustillo, JM Cañive… - Neuroinformatics, 2017 - Springer
In this paper we describe an open-access collection of multimodal neuroimaging data in
schizophrenia for release to the community. Data were acquired from approximately 100 …

Neurophysiological biomarkers for drug development in schizophrenia

DC Javitt, KM Spencer, GK Thaker, G Winterer… - Nature Reviews Drug …, 2008 - nature.com
Schizophrenia represents a pervasive deficit in brain function, leading to hallucinations and
delusions, social withdrawal and a decline in cognitive performance. As the underlying …

Early-stage visual processing deficits in schizophrenia

PD Butler, DC Javitt - Current opinion in psychiatry, 2005 - journals.lww.com
These findings highlight the importance of sensory processing deficits, in addition to higher
cognitive dysfunction, for understanding the pathophysiology of schizophrenia …

Subcortical visual dysfunction in schizophrenia drives secondary cortical impairments

PD Butler, A Martinez, JJ Foxe, D Kim, V Zemon… - Brain, 2007 - academic.oup.com
Visual processing deficits are an integral component of schizophrenia and are sensitive
predictors of schizophrenic decompensation in healthy adults. The primate visual system …