Acetaminophen (APAP) overdose is the clinically most relevant drug hepatotoxicity in
western countries, and, because of translational relevance of animal models, APAP is …

The intestine is a complex organ that promotes digestion, extracts nutrients, participates in
immune surveillance, maintains critical symbiotic relationships with microbiota and affects …

The liver has a critical role in regulating host metabolism, immunity, detoxification, and
homeostasis. Proper liver function is essential for host health, and dysregulation of hepatic …

Hepatocytes, the major metabolic hub of the body, execute functions that are human-
specific, altered in human disease, and currently thought to be regulated through endocrine …

Organoids generated from human pluripotent stem cells provide experimental systems to
study development and disease, but quantitative measurements across different spatial …

Since the recognition that mutations in components of the Wnt–β-catenin pathway underlie
some human cancers, considerable attention has been dedicated to developing therapeutic …

Methods: Organotypic 3D spheroid cultures of primary human or murine hepatocytes were
used to identify the signaling network underlying cell cycle re-entry. Furthermore, we …

Single-cell and spatial molecular profiling assays have shown large gains in sensitivity,
resolution and throughput. Applying these technologies to specimens from human and …

Liver regeneration is a complex process involving the crosstalk between parenchymal and
non-parenchymal cells, especially macrophages. However, the underlying mechanisms …

Liver sinusoidal endothelial cells (LSECs) are key players in maintaining hepatic
homeostasis. They also play crucial roles during liver injury by communicating with liver cell …