The reproductive life span in women starts at puberty and ends at menopause, following the
exhaustion of the follicle stockpile termed the ovarian reserve. Increasing data from …

Cadherins are a group of membrane proteins responsible for cell adhesion. They are crucial
for cell sorting and recognition during the morphogenesis, but they also play many other …

Polycystic ovarian syndrome (PCOS) is one of the most prevalent endocrinopathies and the
leading cause of anovulatory infertility, but its pathogenesis remains elusive. Although HB …

In fetal females, oogonia proliferate immediately after sex determination. The progress of
mitosis in oogonia proceeds so rapidly that the incompletely divided cytoplasm of the sister …

The female reproductive lifespan is largely determined by the size of primordial follicle pool,
which is established following germ cell cyst breakdown around birth. Almost two-third of …

Formation of primordial follicles is a fundamental, early process in mammalian oogenesis.
However, little is known about the underlying mechanisms. We herein report that the RNA …

In female reproduction, the oocyte number is limited after birth. To achieve a continuous
ovulatory cycle, oocytes are stored in primordial follicles. Therefore, the regulation of …

The formation of primordial follicles occurs when germ cell nests break apart and individual
oocytes become surrounded by pregranulosa cells. Why mammalian germ cells develop in …

Zinc oxide nanoparticles (nZnO) have been shown to have higher toxic effects likely due to
their ion-shedding ability and low solubility under neutral conditions. In order to investigate …

In mammals, female fecundity is determined by the size of the primordial follicle (PF) pool,
which is established during the perinatal period. As a non-renewable resource, the …