Neurons of the mammalian central nervous system fail to regenerate. Substantial progress
has been made toward identifying the cellular and molecular mechanisms that underlie …

Retinal circuits transform the pixel representation of photoreceptors into the feature
representations of ganglion cells, whose axons transmit these representations to the brain …

Differential expression analysis in single-cell transcriptomics enables the dissection of cell-
type-specific responses to perturbations such as disease, trauma, or experimental …

Primary somatosensory neurons are specialized to transmit specific types of sensory
information through differences in cell size, myelination, and the expression of distinct …

Amacrine cells (ACs) are a diverse class of interneurons that modulate input from
photoreceptors to retinal ganglion cells (RGCs), rendering each RGC type selectively …

The basic plan of the retina is conserved across vertebrates, yet species differ profoundly in
their visual needs. Retinal cell types may have evolved to accommodate these varied needs …

Classification and characterization of neuronal types are critical for understanding their
function and dysfunction. Neuronal classification schemes typically rely on measurements of …

Retinal ganglion cells (RGCs) are the sole output neurons that transmit visual information
from the retina to the brain. Diverse insults and pathological states cause degeneration of …

Many neurodegenerative diseases cause degeneration of specific types of neurons. For
example, glaucoma leads to death of retinal ganglion cells, leaving other neurons intact …

The development of single-cell RNA sequencing (scRNA-seq) has allowed high-resolution
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …