Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet
of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular …

We have long known that lipids traffic between cellular membranes via vesicles but have
only recently appreciated the role of nonvesicular lipid transport. Nonvesicular transport can …

Phosphatidylinositol 4, 5-bisphosphate (PI (4, 5) P2) is a critically important regulatory lipid
of the plasma membrane (PM); however, little is known about how cells regulate PM PI (4, 5) …

The small GTP ase Rab7 is a key organizer of receptor sorting and lysosomal degradation
by recruiting of a variety of effectors depending on its GDP/GTP‐bound state. However …

Lipids convey both structural and functional properties to eukaryotic membranes.
Understanding the basic lipid composition and the dynamics of these important molecules …

Phospholipids are synthesized primarily within the endoplasmic reticulum and are
subsequently distributed to various subcellular membranes to maintain the unique lipid …

Conspectus Lipids are key components of all organisms. We are well educated in their use
as fuel and their essential role to form membranes. We also know much about their …

Phosphatidylinositol (PI) is an essential structural component of eukaryotic membranes that
also serves as the common precursor for polyphosphoinositide (PPIn) lipids. Despite the …

Today, the importance of autophagy in physiological processes and pathological conditions
is undeniable. Initially, autophagy merely was described as an evolutionarily conserved …

How cytotoxic T lymphocytes (CTLs) sense T cell receptor (TCR) signaling in order to
specialize an area of plasma membrane for granule secretion is not understood. Here, we …