Macrophages phagocytize pathogens to initiate innate immunity and products from the
tumor microenvironment (TME) to mediate tumor immunity. The loss of tumor-associated …

There is now a wealth of evidence showing that communication between microbiota and the
host is critical to sustain the vital functions of the healthy host, and disruptions of this …

Since the first identification of hypoxic cells in sections of carcinomas in the 1950s, hypoxia
has been known as a central hallmark of cancer cells and their microenvironment. Indeed …

There has been an explosion of interest in the signaling capacity of energy metabolites. A
prime example is the Krebs cycle substrate succinate, an archetypal respiratory substrate …

Background Succinate is produced by both host and microbiota, with a key role in the
interplay of immunity and metabolism and an emerging role as a biomarker for inflammatory …

Macrophages are innate phagocytic leukocytes that are highly present in solid tumors,
where they are referred to as tumor-associated macrophages (TAMs). In solid tumors, the …

Understanding how plants grow is critical for agriculture and fundamental for illuminating
principles of multicellular development. Here, we apply desorption electrospray ionization …

Succinate serves as an essential circulating metabolite within the tricarboxylic acid (TCA)
cycle and functions as a substrate for succinate dehydrogenase (SDH), thereby contributing …

Influenza virus infection causes considerable morbidity and mortality, but current therapies
have limited efficacy. We hypothesized that investigating the metabolic signaling during …

The healing process of critical-sized bone defects urges for a suitable biomineralization
environment. However, the unsatisfying repair outcome usually results from a disturbed …