Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases

MAA Al‐Bari - Pharmacology research & perspectives, 2017 - Wiley Online Library
Emerging viruses such as HIV, dengue, influenza A, SARS coronavirus, Ebola, and other
viruses pose a significant threat to human health. Majority of these viruses are responsible …

Oncolytic viruses: newest frontier for cancer immunotherapy

MM Rahman, G McFadden - Cancers, 2021 - mdpi.com
Simple Summary Oncolytic viruses (OVs) are viruses that selectively target and kill cancer
cells while sparing normal ones. OVs are from diverse families of viruses, but naturally …

[HTML][HTML] SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling

F Li, J Li, PH Wang, N Yang, J Huang, J Ou, T Xu… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection-
induced inflammatory responses are largely responsible for the death of novel coronavirus …

A comprehensive review of autophagy and its various roles in infectious, non-infectious, and lifestyle diseases: current knowledge and prospects for disease …

R Khandia, M Dadar, A Munjal, K Dhama, K Karthik… - Cells, 2019 - mdpi.com
Autophagy (self-eating) is a conserved cellular degradation process that plays important
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …

When ferroptosis meets pathogenic infections

J Gao, Q Wang, YD Tang, J Zhai, W Hu, C Zheng - Trends in microbiology, 2023 - cell.com
Apoptosis, necrosis, or autophagy are diverse types of regulated cell death (RCD),
recognized as the strategies that host cells use to defend against pathogens such as …

Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells

Y Gong, N Tang, P Liu, Y Sun, S Lu, W Liu, L Tan… - Autophagy, 2022 - Taylor & Francis
Lacking a self-contained metabolism network, viruses have evolved multiple mechanisms
for rewiring the metabolic system of their host to hijack the host's metabolic resources for …

Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments

H Inoue, K Tani - Cell Death & Differentiation, 2014 - nature.com
Apoptotic cell death generally characterized by a morphologically homogenous entity has
been considered to be essentially non-immunogenic. However, apoptotic cancer cell death …

Oncolytic immunotherapy: dying the right way is a key to eliciting potent antitumor immunity

ZS Guo, Z Liu, DL Bartlett - Frontiers in oncology, 2014 - frontiersin.org
Oncolytic viruses (OVs) are novel immunotherapeutic agents whose anticancer effects come
from both oncolysis and elicited antitumor immunity. OVs induce mostly immunogenic …

Oncolytic viruses-modulated immunogenic cell death, apoptosis and autophagy linking to virotherapy and cancer immune response

YY Wu, TK Sun, MS Chen, M Munir… - Frontiers in Cellular and …, 2023 - frontiersin.org
Recent reports have revealed that oncolytic viruses (OVs) play a significant role in cancer
therapy. The infection of OVs such as oncolytic vaccinia virus (OVV), vesicular stomatitis …

Viruses and autophagy: bend, but don't break

A Jassey, WT Jackson - Nature Reviews Microbiology, 2024 - nature.com
Autophagy is a constitutive cellular process of degradation required to maintain homeostasis
and turn over spent organelles and aggregated proteins. For some viruses, the process can …