Advances in promoter engineering: novel applications and predefined transcriptional control
AP Cazier, J Blazeck - Biotechnology Journal, 2021 - Wiley Online Library
Synthetic biology continues to progress by relying on more robust tools for transcriptional
control, of which promoters are the most fundamental component. Numerous studies have …
control, of which promoters are the most fundamental component. Numerous studies have …
Logomaker: beautiful sequence logos in Python
Sequence logos are visually compelling ways of illustrating the biological properties of DNA,
RNA and protein sequences, yet it is currently difficult to generate and customize such logos …
RNA and protein sequences, yet it is currently difficult to generate and customize such logos …
Figure 1 theory meets figure 2 experiments in the study of gene expression
It is tempting to believe that we now own the genome. The ability to read and rewrite it at will
has ushered in a stunning period in the history of science. Nonetheless, there is an Achilles' …
has ushered in a stunning period in the history of science. Nonetheless, there is an Achilles' …
Genome-wide promoter responses to CRISPR perturbations of regulators reveal regulatory networks in Escherichia coli
Elucidating genome-scale regulatory networks requires a comprehensive collection of gene
expression profiles, yet measuring gene expression responses for every transcription factor …
expression profiles, yet measuring gene expression responses for every transcription factor …
Single-channel selection for EEG-based emotion recognition using brain rhythm sequencing
Recently, electroencephalography (EEG) signals have shown great potential for emotion
recognition. Nevertheless, multichannel EEG recordings lead to redundant data …
recognition. Nevertheless, multichannel EEG recordings lead to redundant data …
MAVE-NN: learning genotype-phenotype maps from multiplex assays of variant effect
Multiplex assays of variant effect (MAVEs) are a family of methods that includes deep
mutational scanning experiments on proteins and massively parallel reporter assays on …
mutational scanning experiments on proteins and massively parallel reporter assays on …
Cell-free gene-regulatory network engineering with synthetic transcription factors
Z Swank, N Laohakunakorn… - Proceedings of the …, 2019 - National Acad Sciences
Gene-regulatory networks are ubiquitous in nature and critical for bottom-up engineering of
synthetic networks. Transcriptional repression is a fundamental function that can be tuned at …
synthetic networks. Transcriptional repression is a fundamental function that can be tuned at …
Deciphering the regulatory genome of Escherichia coli, one hundred promoters at a time
Advances in DNA sequencing have revolutionized our ability to read genomes. However,
even in the most well-studied of organisms, the bacterium Escherichia coli, for≈ 65% of …
even in the most well-studied of organisms, the bacterium Escherichia coli, for≈ 65% of …
De novo design of programmable inducible promoters
X Liu, STP Gupta, D Bhimsaria, JL Reed… - Nucleic Acids …, 2019 - academic.oup.com
Ligand-responsive allosteric transcription factors (aTF) play a vital role in genetic circuits
and high-throughput screening because they transduce biochemical signals into gene …
and high-throughput screening because they transduce biochemical signals into gene …
Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems
A crucial step towards engineering biological systems is the ability to precisely tune the
genetic response to environmental stimuli. In the case of Escherichia coli inducible …
genetic response to environmental stimuli. In the case of Escherichia coli inducible …