In this review, we summarize the multiple functions of NQO1, its established roles in redox
processes and potential roles in redox control that are currently emerging. NQO1 has …

With regards to health, chromium (Cr) is an ambiguous chemical element. Although it is
considered to be an important micronutrient, it also is connected with several pathologies …

NAD (P) H: quinone oxidoreductase 1 (NQO1) is an obligate two-electron reductase that is
involved in chemoprotection and can also bioactivate certain antitumor quinones. This …

Quinones represent a large and diverse class of antitumor drugs and many quinones are
approved for clinical use or are currently undergoing evaluation in clinical trials. For many …

Oxidative stress has been implicated in numerous pathophysiological conditions and also
aging. The tools for studying oxidative stress are now expanding as a result of the human …

The acute leukaemias account for about 30% of all malignancy seen in childhood across the
Western world. A peak incidence of precursor B cell ALL has emerged as socio-economic …

Abstract BACKGROUND: To our knowledge, 17-allylamino, 17-demethoxygeldanamycin
(17AAG) is the first inhibitor of heat shock protein 90 (Hsp90) to enter a phase I clinical trial …

Publisher Summary This chapter provides an overview of NAD (P) H: quinone
oxidoreductase 1 (NQO1). NQO1 is a flavoprotein that is known to catalyze two electron …

Abstract NAD (P) H: quinone oxidoreductase (NQO1) converts benzene-derived quinones to
less toxic hydroquinones and has been implicated in benzene-associated hematotoxicity. A …

Abstract The NAD (P) H: quinone oxidoreductase 1 (NQO1) genotype-phenotype
relationship was examined in individuals with a polymorphism in NQO1. The polymorphism …