Macrophages are distributed in tissues throughout the body and contribute to both
homeostasis and disease. Recently, it has become evident that most adult tissue …

The cornea is a special interface between the internal ocular tissue and the external
environment that provides a powerful chemical, physical, and biological barrier against the …

Macrophages play a crucial role in regeneration and consecutive phases of wound healing.
In this review, we summarise current knowledge on the ontogeny, origin, phenotypical …

Macrophages as innate immune cells with great plasticity are of great interest for cell
therapy. There are two main macrophage populations–pro-and anti-inflammatory cells also …

Abstract Knowledge of how the joint functions as an integrated unit in health and disease
requires an understanding of the stromal cells populating the joint mesenchyme, including …

Macrophages are ubiquitously present innate immune cells in humans and animals
belonging to both invertebrates and vertebrates. These cells were first recognized by Elia …

Resident macrophages play a unique role in the maintenance of tissue function. As
phagocytes, they are an essential first line defenders against pathogens and much of the …

Heart failure represents a systemic disease with profound effects on multiple peripheral
tissues including skeletal muscle. Within the context of heart failure, perturbations in skeletal …

Chronic systemic inflammation is a hallmark feature of obesity and type 2 diabetes. Both
resident and recruited islet macrophages contribute to the proinflammatory milieu of the …

Hematopoietic stem cells (HSCs) and downstream progenitors have long been studied
based on phenotype, cell purification, proliferation, and transplantation into myeloablated …