[HTML][HTML] Breaking free: endocytosis and endosomal escape of extracellular vesicles

L Ribovski, B Joshi, J Gao… - Extracellular Vesicles and …, 2023 - pmc.ncbi.nlm.nih.gov
Extracellular vesicles (EVs) are natural micro-/nanoparticles that play an important role in
intercellular communication. They are secreted by producer/donor cells and subsequent …

Nanoimaging of SARS-CoV-2 viral invasion toward the nucleus and genome

ES Sajidah, K Lim, M Hazawa, RW Wong - Cell Reports Physical Science, 2024 - cell.com
Summary The SARS-CoV-2 virus, responsible for the COVID-19 pandemic, has been linked
to significant worldwide illness and death. Examining the ultrastructure and nanomechanical …

Label-free nonlinear optical signatures of extracellular vesicles in liquid and tissue biopsies of human breast cancer

JE Sorrells, J Park, E Aksamitiene, M Marjanovic… - Scientific reports, 2024 - nature.com
Extracellular vesicles (EVs) have been implicated in metastasis and proposed as cancer
biomarkers. However, heterogeneity and small size makes assessments of EVs challenging …

Chiral and nematic phases of flexible active filaments

Z Dunajova, BP Mateu, P Radler, K Lim, D Brandis… - Nature Physics, 2023 - nature.com
The emergence of large-scale order in self-organized systems relies on local interactions
between individual components. During bacterial cell division, FtsZ—a prokaryotic …

Precise analysis of single small extracellular vesicles using flow cytometry

H Kobayashi, T Shiba, T Yoshida, D Bolidong… - Scientific Reports, 2024 - nature.com
Methods that enable specific and sensitive quantification of small extracellular vesicles
(sEVs) using flow cytometry are still under development. Aggregation or adsorption of …

Nanoscopic Elucidation of Spontaneous Self-Assembly of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Open Reading Frame 6 (ORF6) Protein

G Nishide, K Lim, M Tamura, A Kobayashi… - The Journal of …, 2023 - ACS Publications
Open reading frame 6 (ORF6), the accessory protein of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) that suppresses host type-I interferon signaling, possesses …

[HTML][HTML] Visualization strategies of extracellular vesicles: Illuminating the invisible 'dust'in theranostics

K Zhang, J Hu, Y Hu - Extracellular Vesicle, 2024 - Elsevier
Extracellular vesicles (EVs), lipid bilayer vesicles with diameters of 30-150 nm derived from
nearly all cell types, were once dismissed as “platelet dust” but are now recognized as key …

[HTML][HTML] Recent Advancements in Imaging Techniques for Individual Extracellular Vesicles

T Isogai, KM Hirosawa, KGN Suzuki - Molecules, 2024 - mdpi.com
Extracellular vesicles (EVs), secreted from most cells, are small lipid membranes of vesicles
of 30 to 1000 nm in diameter and contain nucleic acids, proteins, and intracellular …

An Efficient Method for Isolating and Purifying Nuclei from Mice Brain for Single-Molecule Imaging Using High-Speed Atomic Force Microscopy

Y Qiu, ES Sajidah, S Kondo, S Narimatsu, MI Sandira… - Cells, 2024 - mdpi.com
Nuclear pore complexes (NPCs) on the nuclear membrane surface have a crucial function in
controlling the movement of small molecules and macromolecules between the cell nucleus …

Spatiotemporal resolution in high-speed atomic force microscopy for studying biological macromolecules in action

K Umeda, SJ McArthur, N Kodera - Microscopy, 2023 - academic.oup.com
High-speed atomic force microscopy (HS-AFM) is a unique approach that allows direct real-
time visualization of biological macromolecules in action under near-physiological …