[HTML][HTML] Potassium channels in behavioral brain disorders. Molecular mechanisms and therapeutic potential: a narrative review.

KA Alam, P Svalastoga, A Martinez, JC Glennon… - Neuroscience & …, 2023 - Elsevier
Abstract Potassium channels (K+-channels) selectively control the passive flow of potassium
ions across biological membranes and thereby also regulate membrane excitability. Genetic …

KCNQ-encoded potassium channels as therapeutic targets

V Barrese, JB Stott, IA Greenwood - Annual review of …, 2018 - annualreviews.org
Kv7 channels are voltage-gated potassium channels encoded by KCNQ genes that have a
considerable physiological impact in many cell types. This reliance upon Kv7 channels for …

Supramodal numerosity selectivity of neurons in primate prefrontal and posterior parietal cortices

A Nieder - Proceedings of the National Academy of …, 2012 - National Acad Sciences
Numerosity, the number of elements in a set, is a most abstract quantitative category. As
such, it is independent of the sensory modality of its elements, ie, supramodal. Because …

Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277

K Willegems, J Eldstrom, E Kyriakis, F Ataei… - Nature …, 2022 - nature.com
The KCNQ1 ion channel plays critical physiological roles in electrical excitability and K+
recycling in organs including the heart, brain, and gut. Loss of function is relatively common …

Mechanisms of transmission and processing of pain: A narrative review

G Di Maio, I Villano, CR Ilardi, A Messina… - International Journal of …, 2023 - mdpi.com
Knowledge about the mechanisms of transmission and the processing of nociceptive
information, both in healthy and pathological states, has greatly expanded in recent years …

Structural aspects and prediction of calmodulin-binding proteins

C Andrews, Y Xu, M Kirberger, JJ Yang - International journal of …, 2020 - mdpi.com
Calmodulin (CaM) is an important intracellular protein that binds Ca2+ and functions as a
critical second messenger involved in numerous biological activities through extensive …

Insights into cardiac IKs (KCNQ1/KCNE1) channels regulation

X Wu, HP Larsson - International journal of molecular sciences, 2020 - mdpi.com
The delayed rectifier potassium IKs channel is an important regulator of the duration of the
ventricular action potential. Hundreds of mutations in the genes (KCNQ1 and KCNE1) …

Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels

H Yu, Z Lin, ME Mattmann, B Zou… - Proceedings of the …, 2013 - National Acad Sciences
Voltage-gated KCNQ1 (Kv7. 1) potassium channels are expressed abundantly in heart but
they are also found in multiple other tissues. Differential coassembly with single …

Gating and regulation of KCNQ1 and KCNQ1+ KCNE1 channel complexes

Y Wang, J Eldstrom, D Fedida - Frontiers in Physiology, 2020 - frontiersin.org
The IKs channel complex is formed by the co-assembly of Kv7. 1 (KCNQ1), a voltage-gated
potassium channel, with its β-subunit, KCNE1 and the association of numerous accessory …

Arylboronic acids and their myriad of applications beyond organic synthesis

NJ Hiller, NA do Amaral e Silva… - European Journal of …, 2020 - Wiley Online Library
Boron organometallic compounds are mainly known for their great value in organic
synthesis to construct biaryls in Suzuki couplings, for arylations of olefins, for C–S, C–O, and …