Genetic landscape and biomarkers of hepatocellular carcinoma

J Zucman-Rossi, A Villanueva, JC Nault, JM Llovet - Gastroenterology, 2015 - Elsevier
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its
mortality has increased in Western populations, with a minority of patients diagnosed at …

Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications

CM Wong, FHC Tsang, IOL Ng - Nature reviews Gastroenterology & …, 2018 - nature.com
Hepatocellular carcinoma (HCC) is a leading lethal malignancy worldwide. However, the
molecular mechanisms underlying liver carcinogenesis remain poorly understood. Over the …

MicroRNA therapeutics in cancer: current advances and challenges

S Reda El Sayed, J Cristante, L Guyon, J Denis… - Cancers, 2021 - mdpi.com
Simple Summary Cancer is a complex disease associated with deregulation of numerous
genes. In addition, redundant cellular pathways limit efficiency of monotarget drugs in …

Non-coding RNA in hepatocellular carcinoma: mechanisms, biomarkers and therapeutic targets

M Klingenberg, A Matsuda, S Diederichs, T Patel - Journal of hepatology, 2017 - Elsevier
The majority of the human genome is not translated into proteins but can be transcribed into
RNA. Even though the resulting non-coding RNAs (ncRNAs) do not encode for proteins …

Serum exosomal microRNAs as novel biomarkers for hepatocellular carcinoma

W Sohn, J Kim, SH Kang, SR Yang, JY Cho… - … & molecular medicine, 2015 - nature.com
Recent studies have shown that circulating microRNAs are a potential biomarker in various
types of malignancies. The aim of this study was to investigate the feasibility of using serum …

MicroRNA: biogenesis, function and role in cancer

LA MacFarlane, PR Murphy - Current genomics, 2010 - ingentaconnect.com
MicroRNAs are small, highly conserved non-coding RNA molecules involved in the
regulation of gene expression. MicroRNAs are transcribed by RNA polymerases II and III …

Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma

V Hernandez–Gea, S Toffanin, SL Friedman, JM Llovet - Gastroenterology, 2013 - Elsevier
Hepatocellular carcinoma (HCC) is the most common primary liver tumor and the third
greatest cause of cancer-related death worldwide, and its incidence is increasing. Despite …

MicroRNAs in liver disease

G Szabo, S Bala - Nature reviews Gastroenterology & hepatology, 2013 - nature.com
Small, noncoding microRNAs (miRNAs) regulate diverse biological functions in the liver and
increasing evidence suggests that they have a role in liver pathology. This Review …

[HTML][HTML] Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals

BR Carone, L Fauquier, N Habib, JM Shea, CE Hart… - Cell, 2010 - cell.com
Epigenetic information can be inherited through the mammalian germline and represents a
plausible transgenerational carrier of environmental information. To test whether …

Clinical impact of serum exosomal microRNA‐21 as a clinical biomarker in human esophageal squamous cell carcinoma

Y Tanaka, H Kamohara, K Kinoshita, J Kurashige… - Cancer, 2013 - Wiley Online Library
BACKGROUND: Exosomes are 40‐nm to 100‐nm membrane vesicles that are secreted by
various cells, and they play a major role in cell‐cell communication. The objective of this …