Complications of intravitreal injections: 2022

D Patel, SN Patel, V Chaudhary… - Current Opinion in …, 2022 - journals.lww.com
Intravitreal injections continue to be one of the most commonly performed procedures by
ophthalmologists. Although the injections are generally well tolerated, sight-threatening …

Systemic and ocular adverse events with intravitreal anti-VEGF therapy used in the treatment of diabetic retinopathy: a review

JA Zehden, XM Mortensen, A Reddy… - Current Diabetes Reports, 2022 - Springer
Abstract Purpose of Review Intravitreal anti-vascular endothelial growth factor (VEGF)
agents are used routinely in the management of neovascular conditions including …

Targeting ocular drug delivery: an examination of local anatomy and current approaches

E Dosmar, J Walsh, M Doyel, K Bussett, A Oladipupo… - Bioengineering, 2022 - mdpi.com
Ocular drug delivery remains the focus of much modern research. Primary routes of
administration include the surface, the intravitreal space, the subretinal space, and the …

Topical Application of Cell-Penetrating Peptide Modified Anti-VEGF Drug Alleviated Choroidal Neovascularization in Mice

W Hu, W Cai, Y Wu, C Ren, D Yu, T Li… - International Journal …, 2024 - Taylor & Francis
Background Age-related macular degeneration (AMD) stands as the foremost cause of
irreversible central vision impairment, marked by choroidal neovascularization (CNV). The …

Enhanced Ocular Delivery of Beva via Ultra‐Small Polymeric Micelles for Noninvasive Anti‐VEGF Therapy

R Yang, S Tang, X Xie, C Jin, Y Tong… - Advanced …, 2024 - Wiley Online Library
Pathological ocular neovascularization resulting from retinal ischemia constitutes a major
cause of vision loss. Current anti‐VEGF therapies rely on burdensome intravitreal injections …

[HTML][HTML] From randomised controlled trials to real-world data: Clinical evidence to guide management of diabetic macular oedema

PH Gabrielle, H Mehta, D Barthelmes, V Daien… - Progress in Retinal and …, 2023 - Elsevier
Randomised clinical trials (RCTs) are generally considered the gold-standard for providing
scientific evidence for treatments' effectiveness and safety but their findings may not always …

Drug-related adverse effects of antivascular endothelial growth factor agents

PG Iyer, TA Albini - Current opinion in ophthalmology, 2021 - journals.lww.com
Drug-related adverse effects of antivascular endothelial gro... : Current Opinion in Ophthalmology
Drug-related adverse effects of antivascular endothelial growth factor agents : Current Opinion …

Safety review of anti-VEGF therapy in patients with myopic choroidal neovascularization

DSC Ng, M Ho, LPL Iu, TYY Lai - Expert Opinion on Drug Safety, 2022 - Taylor & Francis
Introduction Anti-angiogenesis therapy with intravitreal anti-VEGF agents is now the
standard-of-care treatment for myopic choroidal neovascularization (CNV). Areas covered …

Treatment-emergent adverse events in gene therapy trials for inherited retinal diseases: a narrative review

Y Nuzbrokh, AS Kassotis, SD Ragi, R Jauregui… - Ophthalmology and …, 2020 - Springer
Patient safety is a primary priority in the conduction of retinal gene therapy trials. An
understanding of risk factors and mitigation strategies for post-procedure complications is …

In vitro release of hydrophobic drugs by oleogel rods with biocompatible gelators

R Macoon, M Robey, A Chauhan - European Journal of Pharmaceutical …, 2020 - Elsevier
Purpose Currently, invasive monthly intravitreal injections through the eyeball are required
to deliver retinal drugs. Injections of oleogels into the vitreous have the potential for …