Gene regulatory networks in the evolution and development of the heart

EN Olson - Science, 2006 - science.org
The heart, an ancient organ and the first to form and function during embryogenesis, evolved
by the addition of new structures and functions to a primitive pump. Heart development is …

The Arabidopsis Nitrate Transporter NRT2.4 Plays a Double Role in Roots and Shoots of Nitrogen-Starved Plants

T Kiba, AB Feria-Bourrellier, F Lafouge… - The Plant …, 2012 - academic.oup.com
Plants have evolved a variety of mechanisms to adapt to N starvation. NITRATE
TRANSPORTER2. 4 (NRT2. 4) is one of seven NRT2 family genes in Arabidopsis thaliana …

Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor

DZ Wang, PS Chang, Z Wang, L Sutherland… - Cell, 2001 - cell.com
Serum response factor (SRF) regulates transcription of numerous muscle and growth factor-
inducible genes. Because SRF is not muscle specific, it has been postulated to activate …

The Phosphate Transporter Gene OsPht1;8 Is Involved in Phosphate Homeostasis in Rice

H Jia, H Ren, M Gu, J Zhao, S Sun, X Zhang… - Plant …, 2011 - academic.oup.com
Plant phosphate transporters (PTs) are active in the uptake of inorganic phosphate (Pi) from
the soil and its translocation within the plant. Here, we report on the biological properties …

Two rice phosphate transporters, OsPht1; 2 and OsPht1; 6, have different functions and kinetic properties in uptake and translocation

P Ai, S Sun, J Zhao, X Fan, W Xin, Q Guo… - The Plant …, 2009 - Wiley Online Library
Plant phosphate (Pi) transporters mediate the uptake and translocation of this nutrient within
plants. A total of 13 sequences in the rice (Oryza sativa) genome can be identified as …

OPT3 Is a Phloem-Specific Iron Transporter That Is Essential for Systemic Iron Signaling and Redistribution of Iron and Cadmium in Arabidopsis

Z Zhai, SR Gayomba, H Jung, NK Vimalakumari… - The Plant …, 2014 - academic.oup.com
Iron is essential for both plant growth and human health and nutrition. Knowledge of the
signaling mechanisms that communicate iron demand from shoots to roots to regulate iron …

[HTML][HTML] The cardiac transcription factors Nkx2‐5 and GATA‐4 are mutual cofactors

D Durocher, F Charron, R Warren, RJ Schwartz… - The EMBO …, 1997 - embopress.org
The tissue‐restricted GATA‐4 transcription factor and Nkx2‐5 homeodomain protein are two
early markers of precardiac cells. Both are essential for heart formation, but neither can …

Spatial expression and regulation of rice high-affinity nitrate transporters by nitrogen and carbon status

H Feng, M Yan, X Fan, B Li, Q Shen… - Journal of …, 2011 - academic.oup.com
The high affinity nitrate transport system (HATS) plays an important role in rice nitrogen
acquisition because, even under flooded anaerobic cultivation when NH4+ dominates …

Sizing up the heart: development redux in disease

EN Olson, MD Schneider - Genes & development, 2003 - genesdev.cshlp.org
Following gastrulation and establishment of the three embryonic germ layers, the first
definitive organ to form in the embryo is the heart, whose morphogenesis, growth, and …

Cardiac Septal and Valvular Dysmorphogenesis in Mice Heterozygous for Mutations in the Homeobox Gene Nkx2-5

C Biben, R Weber, S Kesteven, E Stanley… - Circulation …, 2000 - Am Heart Assoc
Heterozygous mutations in the cardiac homeobox gene, NKX2-5, underlie familial cases of
atrial septal defect (ASD) with severe atrioventricular conduction block. In this study, mice …