Crucial role of the pentose phosphate pathway in malignant tumors

L Jin, Y Zhou - Oncology letters, 2019 - spandidos-publications.com
Interest in cancer metabolism has increased in recent years. The pentose phosphate
pathway (PPP) is a major glucose catabolism pathway that directs glucose flux to its …

The role of miR-128 in cancer development, prevention, drug resistance, and immunotherapy

HS Budi, LA Younus, MH Lafta, S Parveen… - Frontiers in …, 2023 - frontiersin.org
A growing body of evidence has revealed that microRNA (miRNA) expression is
dysregulated in cancer, and they can act as either oncogenes or suppressors under certain …

The role of MiRNA in cancer: pathogenesis, diagnosis, and treatment

E Uzuner, GT Ulu, SB Gürler, Y Baran - miRNomics: MicroRNA Biology …, 2022 - Springer
Cancer is also determined by the alterations of oncogenes and tumor suppressor genes.
These gene expressions can be regulated by microRNAs (miRNA). At this point, researchers …

TRIM46 activates AKT/HK2 signaling by modifying PHLPP2 ubiquitylation to promote glycolysis and chemoresistance of lung cancer cells

J Tantai, X Pan, Y Chen, Y Shen, C Ji - Cell Death & Disease, 2022 - nature.com
The incidence of lung cancer is increasing worldwide. Although great progress in lung
cancer treatment has been made, the clinical outcome is still unsatisfactory. Tripartite motif …

A two-miRNA signature (miR-33a-5p and miR-128-3p) in whole blood as potential biomarker for early diagnosis of lung cancer

J Pan, C Zhou, X Zhao, J He, H Tian, W Shen, Y Han… - Scientific reports, 2018 - nature.com
MicroRNAs (MiRNAs) have been found to be dysregulated in lung cancer tissues compared
to their matched paracancerous tissues. However, the roles of miRNAs in peripheral blood …

[HTML][HTML] Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner

C Zheng, X Yu, Y Liang, Y Zhu, Y He, L Liao… - … Pharmaceutica Sinica B, 2022 - Elsevier
As one of the hallmarks of cancer, metabolic reprogramming leads to cancer progression,
and targeting glycolytic enzymes could be useful strategies for cancer therapy. By screening …

Glucose metabolism reprogramming in bladder cancer: hexokinase 2 (HK2) as prognostic biomarker and target for bladder cancer therapy

J Afonso, C Gonçalves, M Costa, D Ferreira, L Santos… - Cancers, 2023 - mdpi.com
Simple Summary Urothelial bladder carcinoma entails significant health costs due to the
high recurrence rates and poor response to standard cisplatin-based treatment. The …

Emergence of microRNAs as key players in cancer cell metabolism

S Subramaniam, V Jeet, JA Clements… - Clinical …, 2019 - academic.oup.com
BACKGROUND Metabolic reprogramming is a hallmark of cancer. MicroRNAs (miRNAs)
have been found to regulate cancer metabolism by regulating genes involved in metabolic …

Tumor suppressor miR-128-3p inhibits metastasis and epithelial–mesenchymal transition by targeting ZEB1 in esophageal squamous-cell cancer

L Zhao, R Li, S Xu, Y Li, P Zhao, W Dong… - Acta biochimica et …, 2018 - academic.oup.com
MicroRNAs (miRNAs) are some short RNAs that regulate multiple biological functions at
post-transcriptional levels, such as tumorigenic processes, inflammatory lesions and cell …

Role and regulation of proapoptotic Bax in oral squamous cell carcinoma and drug resistance

M Alam, T Kashyap, P Mishra, AK Panda… - Head & …, 2019 - Wiley Online Library
Background Bax, a proapoptotic protein but its regulation during oral cancer progression
and resistance remains elusive. Methods A total of 127 samples including adjacent normal …