Background Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are
rare, life-threatening immunologic reactions. Prior studies using electronic health records …

Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) is a predominantly drug-
induced disease, with a mortality rate of 15–20%, that engages the expertise of multiple …

Adverse drug reactions are a public health issue that draws widespread attention, especially
for Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) which have high …

Drug hypersensitivity reactions (DHR) are heterogeneous in their pathomechanisms, clinical
presentation, severity, and outcomes. Novel DHR mechanisms, phenotypes, and endotypes …

Human leukocyte antigen (HLA) is a hallmark genetic marker for the prediction of certain
immune-mediated adverse drug reactions (ADRs). Numerous basic and clinical research …

Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe
dermatological emergencies. The role of cytokines and chemokines in the pathogenesis …

Background Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-
threatening, severe mucocutaneous adverse reactions. Severity prediction at early onset is …

The immunomodulatory effects of regulatory T cells (Tregs) and co-signaling receptors have
gained much attention, as they help balance immunogenic and immunotolerant responses …

Background Bullous skin disorders are induced by different pathomechanisms and several
are emergent, including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) …

Macrolides are one of the most commonly prescribed antibiotics. In several studies, their use
was associated with the occurrence of Stevens‐Johnson syndrome (SJS) and toxic …