Subarachnoid hemorrhage (SAH), predominantly caused by a ruptured aneurysm, is a
devastating neurological disease that has a morbidity and mortality rate higher than 50 …

Thrombin is increased in the brain after hemorrhagic and ischemic stroke primarily due to
the prothrombin entry from blood either with a hemorrhage or following blood-brain barrier …

Subarachnoid hemorrhage is a devastating disease that can be difficult to manage. Not only
is the initial bleeding and rebleeding associated with high mortality, but a large fraction of …

Early brain injury (EBI) has become an area of extreme interest in the recent years and
seems to be a common denominator in the pathophysiology of global transient ischemia and …

Subarachnoid hemorrhage represents a serious disease with high mortality and morbidity.
Two important areas are becoming the central research interest of subarachnoid …

Traumatic brain injury (TBI), which leads to disability, dysfunction, and even death, is a
prominent health problem worldwide with no effective treatment. A brain-permeable …

There is increasing evidence that prothrombin and its active derivative thrombin are
expressed locally in the central nervous system. So far, little is known about the …

Abstract Objects: The major causes of death and disability in subarachnoid hemorrhage
(SAH) may be early brain injury (EBI) and cerebral vasospasm. Although cerebral …

ICH is a disease with high rates of mortality and morbidity, with a substantial public health
impact. Spontaneous ICH (sICH) has been extensively studied, and a large body of data has …

Hemorrhage in the central nervous system (CNS), including intracerebral hemorrhage (ICH),
intraventricular hemorrhage (IVH), and aneurysmal subarachnoid hemorrhage (aSAH) …