A large body of evidence has demonstrated that exposure to childhood maltreatment at any
stage of development can have long-lasting consequences. It is associated with a marked …

We conducted the first meta-analysis of whole-brain voxel-based DTI studies in childhood
maltreatment to elucidate regions of white matter (WM) microstructure abnormality relative to …

Gray matter (GM) abnormalities have been reported in both adults and children/adolescents
with histories of childhood maltreatment (CM). As maturational and compensatory changes …

Childhood trauma (CT) has been repeatedly linked to earlier onset and greater severity of
bipolar disorder (BD) in adulthood. However, such knowledge is mostly based on …

Neuropsychiatric disorders including generalized anxiety disorder (GAD), obsessive-
compulsive disorder (OCD), major depressive disorder (MDD), bipolar disorder (BD), and …

Bipolar disorder (BD) and major depressive disorder (MDD) are severe psychiatric illnesses
that share among their environmental risk factors the exposure to adverse childhood …

Childhood maltreatment increases risk for mood disorders and is associated with earlier
onset—and more pernicious disease course following onset—of mood disorders. While the …

Childhood maltreatment increases the likelihood of developing anxiety disorders in humans.
Early life adversity (ELA) paradigms in rodents produce lasting increases in avoidant and …

Early-life adverse events or childhood adversities (CAs) are stressors and harmful
experiences severely impacting on a child's wellbeing and development. Examples of CAs …

Childhood maltreatment is associated with adverse effects on the brain, and an increased
risk for psychopathology, including mood and substance use disorders. Individuals vary on …