This article addresses the clinical presentation, diagnosis, pathophysiology and
management of narcolepsy type 1 and 2, with a focus on recent findings. A low level of …

The orexins, also known as hypocretins, are two neuropeptides (orexin A and B or
hypocretin 1 and 2) produced by a few thousand neurons located in the lateral …

Study Objectives: This review aimed to summarize current knowledge about disrupted
nighttime sleep (DNS) and sleep instability in narcolepsy, including self-reported and …

Summary Narcolepsy type 1 (NT1) is a lifelong disorder of sleep-wake dysregulation defined
by clinical symptoms, neurophysiological findings, and low hypocretin levels. Besides a role …

Narcolepsy is mainly associated with excessive daytime sleepiness, but the characteristic
feature is abnormal rapid eye movement (REM) sleep phenomena. REM sleep disturbances …

Advances in translational research provide key opportunities to explore the physiological
and pathological effects of sleep in different neurodegenerative diseases. Recent findings …

Abstract Study Objectives To describe the phenotype of narcolepsy with intermediate
cerebrospinal fluid hypocretin-1 levels (CSF hcrt-1). Methods From 1600 consecutive …

Study Objectives: To assess the frequency, determinants, and clinical impact of clinical rapid
eye movement (REM) and non-REM (NREM) parasomnias in adult patients with narcolepsy …

Central Disorders of Hypersomnolence : CONTINUUM: Lifelong Learning in Neurology
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Abstract Study Objectives Despite its high frequency in narcolepsy type 1 (NT1), disrupted
nocturnal sleep (DNS) remains understudied, and its determinants have been poorly …