Purpose This review provides an update on the current clinical, epidemiological and
pathophysiological evidence alongside the diagnostic, prevention and treatment approach …

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequent side
effects caused by antineoplastic agents, with a prevalence from 19% to over 85%. Clinically …

Interactions between central glial cells and neurons in the pain circuitry are critical
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …

Chronic pain affects one in five of the general population and is the third most important
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …

Peripheral neuropathies are characterized by nerves damage and axonal loss, and they
could be classified in hereditary or acquired forms. Acquired peripheral neuropathies are …

Chronic pain affects the life quality of the suffering patients and posts heavy problems to the
health care system. Conventional medications are usually insufficient for chronic pain …

Adenosine receptors (ARs) function in the body's response to conditions of pathology and
stress associated with a functional imbalance, such as in the supply and demand of …

The A3 adenosine receptor (A3AR) has emerged as a therapeutic target with A3AR agonists
to tackle the global challenge of neuropathic pain, and investigation into its mode of action is …

Adenosine is a purine nucleoside, responsible for the regulation of multiple physiological
and pathological cellular and tissue functions by activation of four G protein-coupled …

Pain is a fundamental feature of inflammation. The immune system plays a critical role in the
activation of sensory neurons and there is increasing evidence of neuro-inflammatory …