Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Astrocytes are a large and diverse population of morphologically complex cells that exist
throughout nervous systems of multiple species. Progress over the last two decades has …

The discovery that transient elevations of calcium concentration occur in astrocytes, and
release'gliotransmitters' which act on neurons and vascular smooth muscle, led to the idea …

Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these
cells control blood flow is crucial for understanding how neural computation is powered, for …

Astrocyte Ca2+ signalling has been proposed to link neuronal information in different spatial–
temporal dimensions to achieve a higher level of brain integration. However, some …

Astrocytes communicate with synapses by means of intracellular calcium ([Ca2+] i)
elevations, but local calcium dynamics in astrocytic processes have never been thoroughly …

Human pluripotent stem cells (hPSCs) have been differentiated efficiently to neuronal cell
types. However, directed differentiation of hPSCs to astrocytes and astroglial subtypes …

Astrocytic network alterations have been reported in Alzheimer's disease (AD), but the
underlying pathways have remained undefined. Here we measure astrocytic calcium …

Astrocytes are ideally placed to detect and respond to network activity. They express
ionotropic and metabotropic receptors, and can release gliotransmitters. Astrocytes also …

Research on glial cells over the past 30 years has confirmed the critical role of astrocytes in
pathophysiological brain states. However, most of our knowledge about astrocyte …