The interplay between chromatin, transcription factors and genes generates complex
regulatory circuits that can be represented as gene regulatory networks (GRNs). The study …

Studies with temporal or spatial resolution are crucial to understand the molecular dynamics
and spatial dependencies underlying a biological process or system. With advances in high …

Joint profiling of chromatin accessibility and gene expression in individual cells provides an
opportunity to decipher enhancer-driven gene regulatory networks (GRNs). Here we present …

For more than 100 years, the fruit fly Drosophila melanogaster has been one of the most
studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula …

Enhancers play a central role in the spatiotemporal control of gene expression and tend to
work in a cell-type-specific manner. In addition, they are suggested to be major contributors …

Transcriptional enhancers act as docking stations for combinations of transcription factors
and thereby regulate spatiotemporal activation of their target genes. It has been a long …

In the mammalian liver, hepatocytes exhibit diverse metabolic and functional profiles based
on their location within the liver lobule. However, it is unclear whether this spatial variation …

The human placenta has a vital role in ensuring a successful pregnancy. Despite the
growing body of knowledge about its cellular compositions and functions, there has been …

Single-cell assay for transposase-accessible chromatin using sequencing (scATAC) shows
great promise for studying cellular heterogeneity in epigenetic landscapes, but there remain …

Previous studies have identified topologically associating domains (TADs) as basic units of
genome organization. We present evidence of a previously unreported level of genome …