Unraveling the dichotomy of enigmatic serine protease HtrA2
Mitochondrial high-temperature requirement protease A2 (HtrA2) is an integral member of
the HtrA family of serine proteases that are evolutionarily conserved from prokaryotes to …
the HtrA family of serine proteases that are evolutionarily conserved from prokaryotes to …
Oligomeric assembly regulating mitochondrial HtrA2 function as examined by methyl-TROSY NMR
Human High temperature requirement A2 (HtrA2) is a mitochondrial protease chaperone
that plays an important role in cellular proteostasis and in regulating cell-signaling events …
that plays an important role in cellular proteostasis and in regulating cell-signaling events …
Dissecting the role of interprotomer cooperativity in the activation of oligomeric high-temperature requirement A2 protein
Y Toyama, RW Harkness… - Proceedings of the …, 2021 - National Acad Sciences
The human high-temperature requirement A2 (HtrA2) mitochondrial protease is critical for
cellular proteostasis, with mutations in this enzyme closely associated with the onset of …
cellular proteostasis, with mutations in this enzyme closely associated with the onset of …
Structural basis of substrate recognition and allosteric activation of the proapoptotic mitochondrial HtrA2 protease
EE Aspholm, J Lidman, BM Burmann - Nature Communications, 2024 - nature.com
The mitochondrial serine protease HtrA2 is a human homolog of the Escherichia coli Deg-
proteins exhibiting chaperone and proteolytic roles. HtrA2 is involved in both apoptotic …
proteins exhibiting chaperone and proteolytic roles. HtrA2 is involved in both apoptotic …
Probing allosteric interactions in homo-oligomeric molecular machines using solution NMR spectroscopy
Developments in solution NMR spectroscopy have significantly impacted the biological
questions that can now be addressed by this methodology. By means of illustration, we …
questions that can now be addressed by this methodology. By means of illustration, we …
The Nϵ‐Rule for Serine, but Not Cysteine Catalytic Triads
H Czapinska, M Bochtler - Angewandte Chemie, 2022 - Wiley Online Library
Catalytic triads, composed of a serine or cysteine nucleophile, a histidine, and a third triad
residue (typically Asp/Glu/Asn), are common in enzyme active sites and catalyze a wide …
residue (typically Asp/Glu/Asn), are common in enzyme active sites and catalyze a wide …
Cellular substrates and pro-apoptotic function of the human HtrA4 protease
T Wenta, M Jarzab, M Rychlowski, M Borysiak… - Journal of …, 2019 - Elsevier
The human HtrA4 protein, belonging to the HtrA family of proteases/chaperones, participates
in oncogenesis and placentation, and plays a role in preeclampsia. As the knowledge …
in oncogenesis and placentation, and plays a role in preeclampsia. As the knowledge …
Loss of GSK-3β mediated phosphorylation in HtrA2 contributes to uncontrolled cell death with Parkinsonian phenotype
HtrA2, a proapoptotic mitochondrial serine protease, promotes cellular protection against
oxidative damage. Literature reports show positive correlation between loss of HtrA2 …
oxidative damage. Literature reports show positive correlation between loss of HtrA2 …
Insufficient HtrA2 causes meiotic defects in aging germinal vesicle oocytes
M Gao, Y Qiu, T Cao, D Li, J Wang, Y Jiao… - Reproductive Biology …, 2022 - Springer
Background High-temperature requirement protease A2 (HtrA2/Omi) is a mitochondrial
chaperone that is highly conserved from bacteria to humans. It plays an important role in …
chaperone that is highly conserved from bacteria to humans. It plays an important role in …
[HTML][HTML] INAUGURAL ARTICLE by a Recently Elected Academy Member: Probing allosteric interactions in homo-oligomeric molecular machines using solution NMR …
Y Toyama, LE Kay - Proceedings of the National Academy of …, 2021 - ncbi.nlm.nih.gov
Developments in solution NMR spectroscopy have significantly impacted the biological
questions that can now be addressed by this methodology. By means of illustration, we …
questions that can now be addressed by this methodology. By means of illustration, we …