Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4‐hydroxy‐2‐nonenal
Lipid peroxidation can be described generally as a process under which oxidants such as
free radicals attack lipids containing carbon‐carbon double bond (s), especially …
free radicals attack lipids containing carbon‐carbon double bond (s), especially …
Analysis of glutathione: implication in redox and detoxification
Background: Glutathione is a ubiquitous thiol-containing tripeptide, which plays a central
role in cell biology. It is implicated in the cellular defence against xenobiotics and naturally …
role in cell biology. It is implicated in the cellular defence against xenobiotics and naturally …
Oxidative damage to macromolecules in human Parkinson disease and the rotenone model
LH Sanders, JT Greenamyre - Free Radical Biology and Medicine, 2013 - Elsevier
Parkinson disease (PD), the most common neurodegenerative movement disorder, is
associated with selective degeneration of nigrostriatal dopamine neurons. Although the …
associated with selective degeneration of nigrostriatal dopamine neurons. Although the …
Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8‐hydroxyguanine levels in substantia nigra
ZI Alam, A Jenner, SE Daniel, AJ Lees… - Journal of …, 1997 - Wiley Online Library
Oxidative damage has been implicated in the pathology of Parkinson's disease (PD), eg,
rises in the level of the DNA damage product, 8‐hydroxy‐2′‐deoxyguanosine, have been …
rises in the level of the DNA damage product, 8‐hydroxy‐2′‐deoxyguanosine, have been …
Blood and plasma glutathione measured in healthy subjects by HPLC: relation to sex, aging, biological variables, and life habits
F Michelet, R Gueguen, P Leroy, M Wellman… - Clinical …, 1995 - academic.oup.com
We report an HPLC method for measuring the concentrations of reduced (GSH) and total
(GSHt) free glutathione in human plasma and whole blood. The chromatographic step was …
(GSHt) free glutathione in human plasma and whole blood. The chromatographic step was …
Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization
Lipoic acid (thiotic acid) is being used as a dietary supplement, and as a therapeutic agent,
and is reported to have beneficial effects in disorders associated with oxidative stress, but its …
and is reported to have beneficial effects in disorders associated with oxidative stress, but its …
Oxygen free radicals and Parkinson's disease
JD Adams Jr, IN Odunze - Free Radical Biology and Medicine, 1991 - Elsevier
The involvement of oxygen radicals in the pathogenesis of Parkinson's disease has been
suggested for some time. This article reviews the evidence supporting the involvement of …
suggested for some time. This article reviews the evidence supporting the involvement of …
(E)-4-hydroxy-2-nonenal may be involved in the pathogenesis of Parkinson's disease
ML Selley - Free Radical Biology and Medicine, 1998 - Elsevier
(E)-4-Hydroxy-2-nonenal (HNE) is a toxic end-product of the free radical-stimulated
peroxidation of phospholoipid-bound arachidonic acid in cell membranes. There is a …
peroxidation of phospholoipid-bound arachidonic acid in cell membranes. There is a …
Not all stressors are equal: Mechanism of stressors on RPE cell degeneration
Age-related macular degeneration (AMD) is a major cause of irreversible blindness among
the elderly population. Dysfunction and degeneration of the retinal pigment epithelial (RPE) …
the elderly population. Dysfunction and degeneration of the retinal pigment epithelial (RPE) …