The current achievements in treating glioblastoma (GBM) patients are not sufficient because
many challenges exist, such as tumor heterogeneity, the blood brain barrier, glioma stem …

Glioblastoma (GBM) is an incurable brain tumor with a median survival of approximately 15
months despite an aggressive standard of care that includes surgery, chemotherapy, and …

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, while its
frequency in pediatric patients is 10–15%. For this reason, age is considered one of the …

Tumor microenvironment (TME) is the cornerstone of the occurrence, development, invasion
and diffusion of the malignant central nerve system (CNS) tumor, glioma. As the largest …

In recent years, nanomedicines have emerged as a promising method for central nervous
system drug delivery, enabling the drugs to overcome the blood-brain barrier and …

Ferroptosis is a recently described programmed cell death mechanism that is characterized
by the buildup of iron (Fe)-dependent lipid peroxides in cells and is morphologically …

Glioblastoma (GBM), is the most malignant form of gliomas and the most common and lethal
primary brain tumor in adults. Conventional cancer treatments have limited to no efficacy on …

Glioblastoma (GBM) is the most prevalent and deadly primary brain tumor type, with a
discouragingly low survival rate and few effective treatments. An important function of the …

Human glioblastoma (GBM), the most aggressive brain tumor, comprises six major subtypes
of malignant cells, giving rise to both inter-patient and intra-tumor heterogeneity. The …

Simple Summary Glioblastoma is the most common and malignant primary brain tumor.
Despite intensive research for new treatments, the survival of patients has not significantly …