Background Cancer is an enormous global health burden, and should be effectively
addressed with better therapeutic strategies. Currently, over 60% of the clinically approved …

In the genus Macleaya, Macleaya cordata and Macleaya microcarpa have been recognized
as traditional herbs that are primarily distributed in China, North America, and Europe and …

Effective treatment of lung cancer remains a significant clinical challenge due to its multidrug
resistance and side effects of the current treatment options. The high mortality associated …

Metabolic regulation is largely dependent on mitochondria, which play an important role in
energy homeostasis. Mitochondrial dysfunction results in an imbalanced energy supply to …

Historically, natural products have represented a significant source of anticancer agents,
with plant-derived drugs becoming increasingly explored. In particular, sanguinarine is a …

Sanguinarine is a best-known member of a relatively small group of quaternary benzo [c]
phenanthridine alkaloids (QBAs). QBAs are widely distributed in the family Papaveraceae …

Proteins involved in bacterial cell division often do not have a counterpart in eukaryotic cells
and they are essential for the survival of the bacteria. The genetic accessibility of many …

The identification of rapid, reliable, and highly reproducible biological assays that can be
standardized and routinely used in preclinical tests constitutes a promising approach to …

Mitochondria are semi-autonomous organelles that play essential roles in cellular
metabolism and programmed cell death pathways. Genomic, functional and structural …

This study was aimed at evaluating the potential application of benzophenanthridine
alkaloids, sanguinarine and cheleritrine, in the therapy of melanoma cancer. In vitro …