Krüppel-like factor 4 (KLF4): What we currently know

AM Ghaleb, VW Yang - Gene, 2017 - Elsevier
Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing
transcription factor that regulates diverse cellular processes such as cell growth …

Mammalian Krüppel-like factors in health and diseases

BB McConnell, VW Yang - Physiological reviews, 2010 - journals.physiology.org
The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …

Krüppel-like factors in cancer

MP Tetreault, Y Yang, JP Katz - Nature Reviews Cancer, 2013 - nature.com
Krüppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with
diverse and essential functions in a multitude of cellular processes, including proliferation …

Genomic and epigenetic instability in colorectal cancer pathogenesis

WM Grady, JM Carethers - Gastroenterology, 2008 - Elsevier
Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA …

DNA methylation readers and cancer: mechanistic and therapeutic applications

N Mahmood, SA Rabbani - Frontiers in oncology, 2019 - frontiersin.org
DNA methylation is a major epigenetic process that regulates chromatin structure which
causes transcriptional activation or repression of genes in a context-dependent manner. In …

Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation

AM Ghaleb, MO Nandan, S Chanchevalap, WB Dalton… - Cell research, 2005 - nature.com
Krüppel-like factors (KLFs) are evolutionarily conserved zinc finger-containing transcription
factors with diverse regulatory functions in cell growth, proliferation, differentiation, and …

The diverse functions of Krüppel‐like factors 4 and 5 in epithelial biology and pathobiology

BB McConnell, AM Ghaleb, MO Nandan, VW Yang - Bioessays, 2007 - Wiley Online Library
The Krüppel-like factors (KLFs) comprise a family of evolutionarily conserved zinc finger
transcription factors that regulate numerous biological processes including proliferation …

miR-142-3p attenuates breast cancer stem cell characteristics and decreases radioresistance in vitro

FM Troschel, N Böhly, K Borrmann, T Braun… - tumor …, 2018 - journals.sagepub.com
Effectively targeting cancer stem cells, a subpopulation of tumorigenic, aggressive, and
radioresistant cells, holds therapeutic promise. However, the effects of the microRNA miR …

Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis

D Hu, M Gur, Z Zhou, A Gamper, MC Hung… - Nature …, 2015 - nature.com
KLF4 is an important regulator of cell-fate decision, including DNA damage response and
apoptosis. We identify a novel interplay between protein modifications in regulating KLF4 …

Roles of Krüppel‐like factor 4 in normal homeostasis, cancer and stem cells

PM Evans, C Liu - Acta biochimica et biophysica Sinica, 2008 - Wiley Online Library
Krüppel‐like factor 4 (KLF4) is a zinc finger‐type transcription factor expressed in a variety of
tissues, including the epithelium of the intestine and the skin, and it plays an important role …