Scaffold-based 3D cell culture models in cancer research
Abstract Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer
research, offering significant advantages over traditional two-dimensional (2D) cell culture …
research, offering significant advantages over traditional two-dimensional (2D) cell culture …
Oxygen control: the often overlooked but essential piece to create better in vitro systems
V Palacio-Castañeda, N Velthuijs, S Le Gac… - Lab on a Chip, 2022 - pubs.rsc.org
Variations in oxygen levels play key roles in numerous physiological and pathological
processes, but are often not properly controlled in in vitro models, introducing a significant …
processes, but are often not properly controlled in in vitro models, introducing a significant …
Biosensors to monitor cell activity in 3D hydrogel-based tissue models
Three-dimensional (3D) culture models have gained relevant interest in tissue engineering
and drug discovery owing to their suitability to reproduce in vitro some key aspects of human …
and drug discovery owing to their suitability to reproduce in vitro some key aspects of human …
Continuous flow delivery system for the perfusion of scaffold-based 3D cultures
The paper-based culture platform developed by Whitesides readily incorporates tissue-like
structures into laboratories with established workflows that rely on monolayer cultures. Cell …
structures into laboratories with established workflows that rely on monolayer cultures. Cell …
Engineering the cellular microenvironment of post-infarct myocardium on a chip
Myocardial infarctions are one of the most common forms of cardiac injury and death
worldwide. Infarctions cause immediate necrosis in a localized region of the myocardium …
worldwide. Infarctions cause immediate necrosis in a localized region of the myocardium …
Editors' Choice—Luminescent Oxygen Sensors: Valuable Tools for Spatiotemporal Exploration of Metabolism in In Vitro Systems
A common biological theme on Earth is the importance of oxygen, regardless of an
organism's metabolic capabilities. This commonality makes the quantification of O 2 …
organism's metabolic capabilities. This commonality makes the quantification of O 2 …
Mass Spectrometry–Based Applications of Spheroids in Cancer Biology
BD Fries, AB Hummon - Annual Review of Analytical Chemistry, 2024 - annualreviews.org
The use of cell culture techniques to model human disease is an indispensable tool that has
helped improve the health and well-being of the world. Monolayer cultures have most often …
helped improve the health and well-being of the world. Monolayer cultures have most often …
Engineering tools for regulating hypoxia in tumour models
Major advances in the field of genomic technologies have led to an improvement in cancer
diagnosis, classification and prognostication. However, many cancers remain incurable due …
diagnosis, classification and prognostication. However, many cancers remain incurable due …
Microfluidic-based spatiotemporal control of oxygen concentration in bacteria suspension culture from bulk to the single cells
Q Tang, D Wang, J Cui, Y Zhang, J Mei, J Du, A Xia… - Nano Today, 2024 - Elsevier
Oxygen plays a crucial role in microbial growth and metabolism. However, the detailed
bacterial responses and regulatory mechanisms toward the change of oxygen are still not …
bacterial responses and regulatory mechanisms toward the change of oxygen are still not …
Studies on oxygen availability and the creation of natural and artificial oxygen gradients in gelatin‐methacryloyl hydrogel 3D cell culture
C Schmitz, I Pepelanova, C Ude… - Journal of Tissue …, 2022 - Wiley Online Library
Abstract Three‐dimensional (3D) cultivation platforms allow the creation of cell models,
which more closely resemble in vivo‐like cell behavior. Therefore, 3D cell culture platforms …
which more closely resemble in vivo‐like cell behavior. Therefore, 3D cell culture platforms …