Programmable gene-editing tools have transformed the life sciences and have shown
potential for the treatment of genetic disease. Among the CRISPR–Cas technologies that …

The emergence of CRISPR-Cas systems has accelerated the development of gene editing
technologies, which are widely used in the life sciences. To improve the performance of …

CRISPR-Cas gene editing has revolutionized experimental molecular biology over the past
decade and holds great promise for the treatment of human genetic diseases. Here we …

Clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR–
Cas)-mediated genome editing has revolutionized biomedical research and will likely …

Abstract Homology-directed repair (HDR), a method for repair of DNA double-stranded
breaks can be leveraged for the precise introduction of mutations supplied by synthetic DNA …

Our ability to edit genomes lags behind our capacity to sequence them, but the growing
understanding of CRISPR biology and its application to genome, epigenome and …

Mitochondria must maintain adequate amounts of metabolites for protective and biosynthetic
functions. However, how mitochondria sense the abundance of metabolites and regulate …

Prime editing systems have enabled the incorporation of precise edits within a genome
without introducing double strand breaks. Previous studies defined an optimal primer …

Invasive rodents are a major cause of environmental damage and biodiversity loss,
particularly on islands. Unlike insects, genetic biocontrol strategies including population …

Gene editing ushers in a new era of disease treatment since many genetic diseases are
caused by base-pair mutations in genomic DNA. With the rapid development of genome …