It is well-recognized that, despite similar pain characteristics, some people with chronic pain
recover, whereas others do not. In this review, we discuss possible contributions and …

Hyperalgesia and allodynia are frequent symptoms of disease and may be useful
adaptations to protect vulnerable tissues. Both may, however, also emerge as diseases in …

Most patients who undergo surgery recover uneventfully and resume their normal daily
activities within weeks. Nevertheless, chronic postsurgical pain develops in an alarming …

This review deals with physiological and biological mechanisms of neuropathic pain, that is,
pain induced by injury or disease of the nervous system. Animal models of neuropathic pain …

Chronic pain is a global problem that has reached epidemic proportions. An estimated 20%
of adults suffer from pain, and another 10% are diagnosed with chronic pain each year …

Chronic orofacial pain conditions can be particularly difficult to diagnose and treat because
of their complexity and limited understanding of the mechanisms underlying their aetiology …

Large individual differences in pain sensitivity present a challenge for medical diagnosis
and may be of importance for the development of chronic pain. Variance in pain sensitivity is …

Chronic pain, especially neuropathic pain and cancer pain, is often not adequately treated
by currently available analgesics. Animal models provide pivotal systems for preclinical …

Described here is a comparison of five peripheral sciatic nerve injury models in rats which
all result in various degrees of neuropathic pain symptoms. They are the chronic constriction …

Rodent models of chronic pain may elucidate pathophysiological mechanisms and identify
potential drug targets, but whether they predict clinical efficacy of novel compounds is …