Mapping non-canonical cellular pathways affected by approved medications can accelerate
drug repurposing efforts, which are crucial in situations with a global impact such as the …

Infection with SARs-COV-2 displays increasing fatality with age and underlying co-morbidity,
in particular, with markers of the metabolic syndrome and diabetes, which seems to be …

Aim This study investigated whether therapeutically relevant concentrations of fluoxetine,
which have been shown to reduce plasma glucose and glycated haemoglobin independent …

The identification and quantification of mitochondrial effects of novel antipsychotics
(brexpiprazole, cariprazine, loxapine, and lurasidone) were studied in vitro in pig brain …

Aims Recent data suggest that antidepressants are associated with incident diabetes but the
possible pharmacological mechanism is still questioned. The aim of the present study was to …

Depression is a serious medical condition, typically treated by antidepressants.
Conventional monotherapy can be effective only in 60–80% of patients, thus modern …

Objective Individual studies have reported conflicting effects of selective serotonin reuptake
inhibitors (SSRIs) on glycemia. We systematically reviewed the effects of SSRIs on glycemia …

During pregnancy, the mother develops insulin resistance to shunt nutrients to the growing
fetus. As a result, the maternal islets of Langerhans undergo several changes to increase …

Aims To investigate the effects of the selective serotonin reuptake inhibitors (SSRIs)
sertraline and paroxetine at therapeutically relevant concentrations on beta‐cell mass and …

Plasma membrane ion channels and mitochondrial electron transport complexes (mETC)
are recognized “off targets” for certain drugs. Simvastatin is one such drug, a lipophilic statin …