The events that convert adherent epithelial cells into individual migratory cells that can
invade the extracellular matrix are known collectively as epithelial-mesenchymal transition …

Melanosomes are tissue-specific lysosome-related organelles of pigment cells in which
melanins are synthesized and stored. Analyses of the trafficking and fate of melanosomal …

More than 150 genes have been identified that affect skin color either directly or indirectly,
and we review current understanding of physiological factors that regulate skin …

Background Generalized vitiligo is an autoimmune disease characterized by melanocyte
loss, which results in patchy depigmentation of skin and hair, and is associated with an …

Color loci in mammals are those genetic loci in which mutations can affect pigmentation of
the hair, skin, and/or eyes. In the mouse, over 800 phenotypic alleles are now known, at 127 …

The inherited platelet disorders are an uncommon cause of symptomatic bleeding. They
may be difficult to diagnose (and are likely to be under‐diagnosed) and pose problems in …

Melanogenesis is the unique process of producing pigmented biopolymers that are
sequestered within melanosomes, which provides color to the skin, hair and eyes of animals …

Background Coloration and color patterning belong to the most diverse phenotypic traits in
animals. Particularly, teleost fishes possess more pigment cell types than any other group of …

Biogenesis of lysosome-related organelles complex-1 (BLOC-1) is a ubiquitously expressed
multisubunit protein complex required for the normal biogenesis of specialized organelles of …

In mammals,> 100 genes regulate pigmentation by means of a wide variety of
developmental, cellular, and enzymatic mechanisms. Nevertheless, genes that directly …