Structural and chemical biology of terpenoid cyclases

DW Christianson - Chemical reviews, 2017 - ACS Publications
The year 2017 marks the twentieth anniversary of terpenoid cyclase structural biology: a trio
of terpenoid cyclase structures reported together in 1997 were the first to set the foundation …

Decoding catalysis by terpene synthases

JN Whitehead, NGH Leferink, LO Johannissen… - ACS …, 2023 - ACS Publications
The review by Christianson, published in 2017 on the twentieth anniversary of the
emergence of the field, summarizes the foundational discoveries and key advances in …

Microbial production of limonene and its derivatives: Achievements and perspectives

Y Ren, S Liu, G Jin, X Yang, YJ Zhou - Biotechnology Advances, 2020 - Elsevier
Limonene and its derivatives have great market potential with diverse applications in food,
pharmaceuticals, cosmetics, etc. Commercial production of limonene and its derivatives …

Engineering Rhodosporidium toruloides for limonene production

S Liu, M Zhang, Y Ren, G Jin, Y Tao, L Lyu… - Biotechnology for …, 2021 - Springer
Background Limonene is a widely used monoterpene in the production of food,
pharmaceuticals, biofuels, etc. The objective of this work was to engineer Rhodosporidium …

Structure, catalysis, and inhibition mechanism of prenyltransferase

HY Chang, TH Cheng, AHJ Wang - IUBMB life, 2021 - Wiley Online Library
Isoprenoids, also known as terpenes or terpenoids, represent a large family of natural
products composed of five‐carbon isopentenyl diphosphate or its isomer dimethylallyl …

Enantioselective tail-to-head cyclizations catalyzed by dual-hydrogen-bond donors

DA Kutateladze, DA Strassfeld… - Journal of the American …, 2020 - ACS Publications
Chiral urea derivatives are shown to catalyze enantioselective tail-to-head cyclization
reactions of neryl chloride analogues. Experimental data are consistent with a mechanism in …

Chemical and genetic basis of orange flavor

Z Fan, KA Jeffries, X Sun, G Olmedo, W Zhao… - Science …, 2024 - science.org
Sweet orange (Citrus sinensis) exhibits limited genetic diversity and high susceptibility to
Huanglongbing (HLB). Breeding HLB-tolerant orange-like hybrids is in dire need. However …

Structural basis of catalysis in the bacterial monoterpene synthases linalool synthase and 1, 8-cineole synthase

V Karuppiah, KE Ranaghan, NGH Leferink… - Acs …, 2017 - ACS Publications
Terpenoids form the largest and stereochemically most diverse class of natural products,
and there is considerable interest in producing these by biocatalysis with whole cells or …

Plasticity engineering of plant monoterpene synthases and application for microbial production of monoterpenoids

D Lei, Z Qiu, J Qiao, GR Zhao - Biotechnology for biofuels, 2021 - Springer
Plant monoterpenoids with structural diversities have extensive applications in food,
cosmetics, pharmaceuticals, and biofuels. Due to the strong dependence on the …

Achievements and perspectives of synthetic biology in botanical insecticides

S Wang, C Zhan, R Chen, W Li, H Song… - Journal of cellular …, 2024 - Wiley Online Library
Botanical insecticides are the origin of all insecticidal compounds. They have been widely
used to control pests in crops for a long time. Currently, the commercial production of …