Polygenic risk scores (PRSs) aggregate the many small effects of alleles across the human
genome to estimate the risk of a disease or disease-related trait for an individual. The …

Loss of functional β-cell mass is the key mechanism leading to the two main forms of
diabetes mellitus—type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) …

This chapter serves as an update and replaces the 2018 ISPAD consensus guideline on
definition, epidemiology, and classification of diabetes in children and adolescents. 1 It …

Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …

We present the Polygenic Score (PGS) Catalog (https://www. PGSCatalog. org), an open
resource of published scores (including variants, alleles and weights) and consistently …

Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision
medicine. However, the major ethical and scientific challenge surrounding clinical …

Most screening programs to identify individuals at risk for type 1 diabetes have targeted
relatives of people living with the disease to improve yield and feasibility. However,∼ 90 …

Prediction of disease risk is an essential part of preventative medicine, often guiding clinical
management. Risk prediction typically includes risk factors such as age, sex, family history of …

ISPAD clinical practice consensus guidelines 2022: Stages of type 1 diabetes in children and
adolescents Page 1 ISPAD GUIDELINES ISPAD clinical practice consensus guidelines 2022 …

The convergence of advances in medical science, human biology, data science, and
technology has enabled the generation of new insights into the phenotype known as …