Crohn's disease can affect any part of the gastrointestinal tract; however, current European
and national guidelines worldwide do not differentiate between small-intestinal and colonic …

The mitochondrion is also a major site for maintaining redox homeostasis between reactive
oxygen species (ROS) generation and scavenging. The quantity, quality, and functional …

Background Crohn's disease (CD), an inflammatory bowel disease (IBD) subtype, results
from pathologic interactions between host cells and its resident gut microbes. CD manifests …

Autophagy is a biological phenomenon whereby components of cells can self-degrade
using autophagosomes. During this process, cells can clear dysfunctional organelles or …

Background Inflammatory bowel disease (IBD) involves chronic T cell–mediated
inflammatory responses. Vedolizumab (VDZ), a monoclonal antibody against α4β7 integrin …

Crohn's disease (CD) is an inflammatory bowel disease (IBD) with complex clinical
manifestations such as chronic diarrhea, weight loss and hematochezia. Despite the …

Abstract Background and Aims Intestinal fibrosis is a common complication of Crohn's
disease [CD]. It is characterised by an accumulation of fibroblasts differentiating into …

Inflammatory bowel diseases (IBD) are systemic immune-mediated conditions with
predilection for the gastrointestinal tract and include Crohn's disease and ulcerative colitis …

Summary Background Ileal and colonic Crohn's disease seem to be two separate entities.
Aims To describe the main physiological distinctions between the small and the large …

METHODS: We conducted a post hoc analysis of the TAILORIX randomized controlled trial,
which studied biologic-naïve patients with active CD and endoscopic ulcers receiving IFX …