Ageing, in a natural way, leads to the gradual worsening of the functional capacity of all
systems and, eventually, to death. This process is strongly associated with higher metabolic …

The proteasome is a well-identified therapeutic target for cancer treatment. It acts as the
main protein degradation system in the cell and degrades key mediators of cell growth …

Damage accumulated in the genome and macromolecules is largely attributed to increased
oxidative damage and a lack of damage repair in a cell, and this can eventually trigger the …

Skin health is heavily affected by ultraviolet irradiation from the sun. In addition, senile skin is
characterized by major changes in the collagen, elastin and in the hyaluronan content …

Some of the greatest challenges in medicine are the neurodegenerative diseases (NDs),
which remain without a cure and mostly progress to death. A companion study employed a …

Background Prolonged maintenance of proteome stability and functionality (proteostasis) is
of emerging significance in aging retardation and healthspan. Purpose An enriched …

Defective proteostasis is associated with the gradual accumulations of misfolded proteins
and is a hallmark of many age-associated neurodegenerative diseases. In the aged brain …

Ultraviolet (UV) light is known to potentially damage human skin and accelerate the skin
aging process. Upon UVB exposure, melanocytes execute skin protection by increasing …

Objectives Pulmonary arterial hypertension (PAH) is a condition characterized by an
increased resistance of pulmonary vasculature, culminating in an increase in pulmonary …

Loss of proteome fidelity leads to the accumulation of non-native protein aggregates and
oxidatively damaged species: hallmarks of an aged cell. These misfolded and aggregated …