Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders affecting
cortisol biosynthesis. Reduced activity of an enzyme required for cortisol production leads to …

Androgens are essential sex steroid hormones for both sexes. Testosterone (T) is the
predominant androgen in males, while in adult females, T concentrations are about 15-fold …

Ferroptosis is a form of necrotic cell death caused by iron-dependent peroxidation of
polyunsaturated phospholipids on cell membranes and is actively suppressed by the …

Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

Adrenal insufficiency continues to be a challenge for patients, their physicians, and
researchers. During the past decade, long-term studies have shown increased mortality and …

Congenital adrenal hyperplasia is a group of autosomal recessive disorders encompassing
enzyme deficiencies in the adrenal steroidogenesis pathway that lead to impaired cortisol …

Context: Androgen excess is a defining feature of polycystic ovary syndrome (PCOS), but the
exact origin of hyperandrogenemia remains a matter of debate. Recent studies have …

Androgens play an important role in metabolic homeostasis and reproductive health in both
men and women. Androgen signalling is dependent on androgen receptor activation, mostly …

Context: Recent studies examining brown adipose tissue (BAT) metabolism in adult humans
have provided convincing evidence of its thermogenic potential and role in clearing …

Background: Anaplastic thyroid carcinomas (ATCs) are among the most lethal malignancies,
for which there is no effective treatment. Objective: In the present study, we aimed to …